皮肤固有 γδ T 细胞的功能。
Functions of skin-resident γδ T cells.
机构信息
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Cell Mol Life Sci. 2011 Jul;68(14):2399-408. doi: 10.1007/s00018-011-0702-x. Epub 2011 May 11.
Abstract
The murine epidermis contains resident T cells that express a canonical γδ TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low levels of cytokines and growth factors that contribute to epidermal homeostasis. Upon activation, DETC can secrete large amounts of inflammatory molecules which participate in the communication between DETC, neighboring keratinocytes and langerhans cells. Chemokines produced by DETC may recruit inflammatory cells to the epidermis. In addition, cell-cell mediated immune responses also appear important for epidermal-T cell communication. Information is provided which supports a crucial role for DETC in inflammation, wound healing, and tumor surveillance.
摘要
小鼠表皮含有表达经典 γδ TCR 的固有 T 细胞，这些细胞来源于胎儿胸腺前体。这些细胞被称为树突状表皮 T 细胞（DETC），它们在成年动物中使用受皮肤限制的 TCR。DETC 产生低水平的细胞因子和生长因子，有助于表皮的稳态。激活后，DETC 可以分泌大量的炎症分子，参与 DETC、邻近角质形成细胞和朗格汉斯细胞之间的通讯。DETC 产生的趋化因子可能招募炎症细胞进入表皮。此外，细胞间的免疫反应似乎对表皮 T 细胞的通讯也很重要。有资料表明，DETC 在炎症、伤口愈合和肿瘤监测中起着至关重要的作用。
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