多粘菌素对奇异变形杆菌脂多糖缺陷型突变体的影响。
Effect of polymyxins on the lipopolysaccharide-defective mutants of Proteus mirabilis.
作者信息
Kaca W, Radziejewska-Lebrecht J, Bhat U R
机构信息
Institute of Microbiology, University of Lódź, Poland.
出版信息
Microbios. 1990;61(246):23-32.
The effects of polymyxins (Pmx) B and E on smooth and rough Proteus mirabilis strains were investigated. P. mirabilis mutant R4/028 which completely lacked 4-amino-4-deoxy-L-arabinose was sensitive towards both polymyxins, and the other P. mirabilis strains investigated were resistant. Lipopolysaccharide (LPS) from Pmx-sensitive R4/028 strain, binds 50% more Pmx B than LPS derived from resistant P. mirabilis strains. The presence of iodoacetamide, N-ethylmaleimide and chloramphenicol rendered the Pmx-resistant P. mirabilis strains sensitive towards both polymyxins.
研究了多粘菌素（Pmx）B和E对奇异变形杆菌光滑型和粗糙型菌株的影响。完全缺乏4-氨基-4-脱氧-L-阿拉伯糖的奇异变形杆菌突变体R4/028对两种多粘菌素均敏感，而所研究的其他奇异变形杆菌菌株具有抗性。来自对多粘菌素敏感的R4/028菌株的脂多糖（LPS）比来自抗性奇异变形杆菌菌株的LPS结合多粘菌素B的能力高50%。碘乙酰胺、N-乙基马来酰亚胺和氯霉素的存在使对多粘菌素耐药的奇异变形杆菌菌株对两种多粘菌素均敏感。
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