Abrahamsen Bo, Rubin Katrine Hass, Brixen Kim
Klinisk Institut, Syddansk Universitet, Denmark.
Ugeskr Laeger. 2011 May 9;173(19):1349-52.
The decision to initiate anti-osteoporotic treatment in Denmark relies on the presence of risk factors combined with a low bone mineral density or on previous low energy fracture, but does not take into account factors like residual life expectancy or the complex relationship between age, bone mineral density and risk factors. The WHO FRAX tool estimates the ten-year risk of osteoporotic fractures by superimposing national fracture and mortality rates on a generalized risk model derived from large studies. As a version adapted for Denmark has now become available, we discuss the strengths and limitations and the impact on clinical decision-making and health policy.
在丹麦,启动抗骨质疏松治疗的决策取决于风险因素的存在以及低骨矿物质密度,或既往的低能量骨折情况,但并未考虑剩余预期寿命或年龄、骨矿物质密度与风险因素之间的复杂关系等因素。世界卫生组织的FRAX工具通过将国家骨折和死亡率叠加到源自大型研究的通用风险模型上,来估计骨质疏松性骨折的十年风险。由于现已推出适用于丹麦的版本,我们讨论了其优势和局限性以及对临床决策和卫生政策的影响。