Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY 10003, USA.
J Glaucoma. 2012 Aug;21(6):415-20. doi: 10.1097/IJG.0b013e3182182551.
To investigate the correlation between structural and functional damage in patients with asymmetric glaucoma using a newly developed short duration transient visual evoked potential (SD-tVEP) device.
Twenty-five patients with visual acuity ≥20/30 and asymmetric visual field (VF) loss [inter-eye difference in mean deviation index (MD) of at least 3 dB] were enrolled. Patients underwent optical coherence tomography (OCT) for macular thickness measurement, scanning laser polarimetry with variable corneal compensation for retinal nerve fiber layer measurement, and SD-tVEP (10% and 85% Michelson contrast, acquisition time of 20 s) in both eyes within 2 months. We correlated VF MD and structural test results with SD-tVEP P100 latency and Delta Amplitude (N75-P100).
Using 10% contrast, there was a significant difference in SD-tVEP latency and amplitude between eyes with better and worse VF MD (P<0.001). MD correlated significantly with both SD-tVEP parameters (r>0.33, P≤0.01). When using 85% contrast, SD-tVEP amplitude differed between eyes (P=0.01) and MD values correlated significantly with amplitude results (r=0.32, P=0.01), but not with latency (P=0.46). In eyes with more advanced VF loss, there was a positive and significant correlation between SD-tVEP amplitude (85% contrast) and macular thickness on OCT (r=0.47, P=0.01), but not with retinal nerve fiber layer measured with polarimetry (P=0.26).
In cases of asymmetric glaucoma, SD-tVEP results correlate significantly with the level of VF damage as measured by MD. In the eyes with more advanced VF loss, reduced SD-tVEP amplitude was associated with decreased macular thickness on OCT. These findings suggest that SD-tVEP may be a fast and objective method to assess or screen for functional damage in glaucomatous eyes.
使用新开发的短时间瞬态视觉诱发电位（SD-tVEP）设备研究不对称性青光眼患者的结构和功能损伤之间的相关性。
共纳入 25 例视力≥20/30 且存在不对称性视野（VF）损失的患者[双眼间平均偏差指数（MD）差异至少为 3 dB]。患者在 2 个月内双眼均接受光学相干断层扫描（OCT）以测量黄斑厚度、带有可变角膜补偿的扫描激光偏振测量以测量视网膜神经纤维层，并进行 SD-tVEP（10%和 85%的 Michelson 对比度，采集时间 20 秒）。我们将 VF MD 和结构测试结果与 SD-tVEP P100 潜伏期和 Delta 幅度（N75-P100）相关联。
使用 10%的对比度，VF MD 较好和较差的眼之间的 SD-tVEP 潜伏期和振幅存在显著差异（P<0.001）。MD 与两个 SD-tVEP 参数均显著相关（r>0.33，P≤0.01）。使用 85%的对比度时，眼间的 SD-tVEP 振幅存在差异（P=0.01），MD 值与振幅结果显著相关（r=0.32，P=0.01），但与潜伏期无关（P=0.46）。在 VF 损失更严重的眼中，SD-tVEP 振幅（85%对比度）与 OCT 测量的黄斑厚度之间存在显著的正相关（r=0.47，P=0.01），但与偏振测量的视网膜神经纤维层无关（P=0.26）。
在不对称性青光眼的情况下，SD-tVEP 结果与 MD 测量的 VF 损伤水平显著相关。在 VF 损失更严重的眼中，SD-tVEP 振幅降低与 OCT 测量的黄斑厚度降低有关。这些发现表明，SD-tVEP 可能是评估或筛查青光眼眼中功能性损伤的一种快速和客观的方法。
