砷酸盐酯水解动力学的理论建模：对 As-DNA 稳定性的启示。
Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA.
机构信息
Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic.
出版信息
Phys Chem Chem Phys. 2011 Jun 21;13(23):10869-71. doi: 10.1039/c1cp20423h. Epub 2011 May 11.
PMID:21562664
Abstract
Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.
摘要
量子化学计算表明，空间位阻或非极性溶剂环境都不能降低砷酸酯的高水解速率。这些结果不仅对水溶液中，而且对非水环境中 As-DNA 的稳定性提出了质疑。
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