Prilepskaia S I, Baryshnikov E N, Kosacheva T A, Parfenov A I, Lazebnik L B
Eksp Klin Gastroenterol. 2011(2):22-6.
Aim was to assess the diagnostic value of the alarm symptoms (AS's) in subjects with constipation based on prospective examination of adult population.
MATERIAL & METHODS: Data was collected from 1189 randomly selected subjects older than 18 y.o. we used specially designed Questionnaire, which included questions for constipation and AS's (such as rectal bleeding, weight loss, permanent intensive abdominal pain, fever and family history of colorectal cancer (CRC)). Subjects with either constipation or AS (s) were offered to do endoscopy.
Any of the AS (s) was registered in 11.3%. After survey 300 subjects were supposed to do endoscopy. 222 (74%) subjects agreed to be undergone rectoscopy and colonoscopy. The prevalence of colon diverticulosis was 16.2%, the prevalence of colorectal polyp (s)--10.8%, CRC--4.5%. The highest predictive value for CRC had the combination of symptoms: rectal bleeding+family history of CRC--50%, the lowest--abdominal pain (4.8%).
The combination of symptoms: rectal bleeding + family history of CRC has the highest predictive value for CRC.
目的是通过对成年人群的前瞻性检查来评估警报症状（AS）在便秘患者中的诊断价值。
从1189名随机选取的18岁以上受试者中收集数据。我们使用了专门设计的问卷，其中包括关于便秘和AS（如直肠出血、体重减轻、持续性剧烈腹痛、发热以及结直肠癌（CRC）家族史）的问题。有便秘或AS的受试者被建议进行内镜检查。
11.3%的受试者出现了任何一种AS。调查后，300名受试者被建议进行内镜检查。222名（74%）受试者同意接受直肠镜和结肠镜检查。结肠憩室病的患病率为16.2%，结直肠息肉的患病率为10.8%，CRC为4.5%。对CRC预测价值最高的症状组合是：直肠出血+CRC家族史——50%，最低的是腹痛（4.8%）。
症状组合：直肠出血+CRC家族史对CRC具有最高的预测价值。
