Daudon Michel, Knebelmann Bertrand
Laboratoire Cristal, service de biochimie A, hôpital Necker-Enfants malades, AP-HP, 75743 Paris Cedex 15.
Rev Prat. 2011 Mar;61(3):385-8.
Calcium oxalate is now the main form of nephrolithiasis in most countries. It may result from unfrequent genetic or acquired diseases, the diagnosis of which being of a major importance for an effective treatment to protect against stone recurrence and renal failure. A more common cause of calcium oxalate nephrolithiasis is the conjonction of inappropriate dietary habits and/or low diuresis in subjects who are particularly susceptible to these factors because of an inherited trait. In such cases, an identification of biological factors involved in the crystallization risk related to the dietary factors is required in order to advise efficient preventive measures against stone recurrence. The use of drugs should be limited to nephrolithiasis that cannot be controlled by diuresis and dietary advices.
草酸钙现在是大多数国家肾结石的主要形式。它可能由罕见的遗传或后天疾病引起，对这些疾病的诊断对于预防结石复发和肾衰竭的有效治疗至关重要。草酸钙肾结石更常见的原因是，由于遗传特征，一些特别易受这些因素影响的人饮食习惯不当和/或尿量过少。在这种情况下，需要确定与饮食因素相关的结晶风险所涉及的生物学因素，以便给出有效的预防结石复发的措施建议。药物的使用应仅限于不能通过利尿和饮食建议控制的肾结石。
