Dahan Elie, Ben Simon Guy J
Department of Ophthalmology, Oxford Eye Center, University of Witwatersrand, Johannesburg, South Africa.
Ophthalmic Surg Lasers Imaging. 2011 May-Jun;42(3):196-201. doi: 10.3928/15428877-20110420-01.
To report on a new surgical technique for neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy or retinal vein occlusion.
Fourteen eyes of 13 patients underwent an augmented trabeculectomy for NVG between January 2000 and February 2003. The augmented trabeculectomy consisted of a 7 × 5 × 5 mm trapezoidal scleral flap, a 6 × 4 × 4 mm deep sclerectomy, application of mitomycin C (MMC) 0.2% for 3 minutes in the deep scleral bed, a 2 × 1 mm trabeculectomy, and the use of a hydrophilic implant (T-flux; Carl Zeiss Meditec, Wetzlar, Germany) as a wick drain connecting the posterior chamber and the deep sclerectomy via a peripheral iridectomy. Whenever the intraocular pressure (IOP) rose above 20 mm Hg, the site of filtration was surgically revised and MMC 0.2% was reapplied in the deep scleral bed.
IOP decreased from a mean of 38.7 ± 5.2 mm Hg preoperatively to a mean of 17.3 ± 5.2 mm Hg postoperatively after a mean follow-up of 32 ± 12 months (P = .001, Wilcoxon signed-ranked test, two related samples). Mean visual acuity improved from 20/350 to 20/170 (P = .034). Seven eyes (50%) needed one surgical revision and one eye (7%) needed two surgical revisions within 3 months from the first operation to maintain an IOP of less than 21 mm Hg.
The modified trabeculectomy augmented by MMC 0.2% and the use of the T-flux as a wick drain can provide adequate IOP control in NVG caused by proliferative diabetic retinopathy or retinal vein occlusion. To maintain an IOP of less than 21 mm Hg without anti-glaucoma medications, surgical revisions of the filtration site are necessary in at least 50% of patients.
报告一种针对增殖性糖尿病视网膜病变或视网膜静脉阻塞患者的新生血管性青光眼(NVG)的新手术技术。
2000年1月至2003年2月期间,13例患者的14只眼睛接受了用于NVG的改良小梁切除术。改良小梁切除术包括制作一个7×5×5毫米的梯形巩膜瓣、一个6×4×4毫米的深层巩膜切除术、在深层巩膜床应用0.2%的丝裂霉素C(MMC)3分钟、一个2×1毫米的小梁切除术,以及使用亲水性植入物(T-flux;德国韦茨拉尔卡尔蔡司医疗技术公司)作为引流条,通过周边虹膜切除术连接后房和深层巩膜切除术。每当眼压(IOP)升至20毫米汞柱以上时,对滤过部位进行手术修复,并在深层巩膜床重新应用0.2%的MMC。
平均随访32±12个月后,眼压从术前的平均38.7±5.2毫米汞柱降至术后的平均17.3±5.2毫米汞柱(P = 0.001,Wilcoxon符号秩和检验,两个相关样本)。平均视力从20/350提高到20/170(P = 0.034)。从首次手术起3个月内,7只眼睛(50%)需要进行一次手术修复,1只眼睛(7%)需要进行两次手术修复,以维持眼压低于21毫米汞柱。
采用0.2%的MMC改良小梁切除术并使用T-flux作为引流条,可有效控制由增殖性糖尿病视网膜病变或视网膜静脉阻塞引起的NVG的眼压。为在不使用抗青光眼药物的情况下维持眼压低于21毫米汞柱,至少50%的患者需要对滤过部位进行手术修复。