Iwakawa Tokiko, Tsuji Takahiro, Hamada Tomonori, Kamio Masaki, Matsuo Takashi, Yoshinaga Mitsuhiro, Kitajima Shinichi, Douchi Tsutomu
Department of Obstetrics and Gynecology, Faculty of Medicine, Sakuragaoka, Kagoshima, Japan.
J Obstet Gynaecol Res. 2011 Oct;37(10):1474-7. doi: 10.1111/j.1447-0756.2011.01528.x. Epub 2011 May 12.
Malignant fibrous histiocytoma (MFH) of the vulva is extremely rare; to date, there have been nine case reports. Almost all of these cases involved middle-aged women. We encountered a 21-year-old woman with a 4.5 × 2.6 cm superficial, localized, exophytic tumor of the right vulva. Microscopic findings on punch biopsy of the tumor initially suggested a vulvar sarcoma. The patient underwent wide local excision of the vulva. The extirpated specimen demonstrated the pleomorphic type of MFH with myxoid stroma of the vulva. The clinical stage was found to be IIB, based on the American Joint Committee on Cancer staging system. Chromosomal analysis of the tumor using the conventional G-band method was normal (46XX). This seems to be a very rare case of MFH of the vulva in a young woman. Physicians should therefore include MFH in the differential diagnosis of vulvar tumors, even though it is a rare disease.
外阴恶性纤维组织细胞瘤（MFH）极为罕见；迄今为止，仅有9例病例报告。几乎所有这些病例都涉及中年女性。我们遇到一名21岁女性，其右侧外阴有一个4.5×2.6厘米大小的浅表、局限性、外生性肿瘤。肿瘤穿刺活检的显微镜检查结果最初提示为外阴肉瘤。患者接受了外阴广泛局部切除术。切除标本显示为外阴多形性MFH伴黏液样基质。根据美国癌症联合委员会分期系统，临床分期为IIB期。使用传统G带方法对肿瘤进行染色体分析结果正常（46XX）。这似乎是年轻女性中极为罕见的外阴MFH病例。因此，尽管MFH是一种罕见疾病，但医生在对外阴肿瘤进行鉴别诊断时应将其纳入考虑。
