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IBDSim:一个用于模拟距离隔离下基因型数据的计算机程序。

IBDSim: a computer program to simulate genotypic data under isolation by distance.

机构信息

Muséum National d'Histoire Naturelle, UMR 5202 CNRS/MNHN 'Origine, Structure et Evolution de la Biodiversité', Paris, France, INRA, UMR CBGP (INRA/IRD/Cirad/Montpellier SupAgro), Campus International de Baillarguet CS 30 016 F-34988, Montferrier-sur-Lez cedex, France, Université Montpellier 2, CNRS, Institut des sciences de l'Évolution, Montpellier, France.

出版信息

Mol Ecol Resour. 2009 Jan;9(1):107-9. doi: 10.1111/j.1755-0998.2008.02417.x. Epub 2008 Nov 10.

Abstract

IBDSim is a package for the simulation of genotypic data under isolation by distance. It is based on a backward 'generation by generation' coalescent algorithm allowing the consideration of various isolation by distance models with discrete subpopulations as well as continuous populations. Many dispersal distributions can be considered as well as heterogeneities in space and time of the demographic parameters. Typical applications of our program include (i) the study of the effect of various sampling, mutational and demographic factors on the pattern of genetic variation; and (ii) the production of test data sets to assess the influence of these factors on inferential methods available to analyse genotypic data.

摘要

IBDSim 是一个用于模拟距离隔离下基因型数据的包。它基于一个向后的“一代一代”合并算法,允许考虑具有离散亚群和连续群体的各种距离隔离模型。许多扩散分布以及人口参数在空间和时间上的异质性都可以被考虑。我们程序的典型应用包括:(i)研究各种采样、突变和人口因素对遗传变异模式的影响;(ii)生成测试数据集,以评估这些因素对分析基因型数据的现有推断方法的影响。

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