Benton L A, Yates F E
Department of Medicine, University of California, Los Angeles 90025.
Am J Physiol. 1990 Mar;258(3 Pt 2):R578-90. doi: 10.1152/ajpregu.1990.258.3.R578.
We examined adrenal blood flow, cortisol secretion rate, concentration of cortisol in adrenal venous blood, mean arterial blood pressure, and heart rate in unrestrained conscious dogs, sampling at 15-20 s, 5 min, or 10 min during experiments lasting from 30 min to 8 h. Time history analysis designed for short, noisy time series detected three significant ultradian oscillatory periods: approximately 3, 6, and 90 min. Circulatory variables (systemic mean arterial pressure, heart rate, and adrenal blood flow) showed all three. Cortisol secretion rate showed the 3- and 90-min oscillations but not the 6-min oscillation. Adrenal glucocorticoid secretion rate and adrenal blood flow were not strongly coupled. However, at one extreme of blood flow (close to zero) and at the opposite extreme (very high blood flow stimulated by adrenocorticotropic hormone) adrenal blood flow and cortisol secretion were tightly coupled. In the normal physiological range, the multiperiodic, rhythmic organization of circulatory variables and adrenal glucocorticoid function arises from independent or only weakly coupled oscillators, not necessarily harmonically related, manifesting near-periodicity with wobble and intermittency.
我们对未加束缚的清醒犬的肾上腺血流、皮质醇分泌率、肾上腺静脉血中皮质醇浓度、平均动脉血压和心率进行了检测，在持续30分钟至8小时的实验过程中，每隔15 - 20秒、5分钟或10分钟进行一次采样。针对短时间、有噪声的时间序列设计的时间历程分析检测到三个显著的超日振荡周期：约3分钟、6分钟和90分钟。循环变量（全身平均动脉血压、心率和肾上腺血流）均显示出这三个周期。皮质醇分泌率显示出3分钟和90分钟的振荡，但未显示出6分钟的振荡。肾上腺糖皮质激素分泌率与肾上腺血流之间没有紧密的耦合关系。然而，在血流的一个极端情况（接近零）和相反极端情况（促肾上腺皮质激素刺激引起的非常高的血流）下，肾上腺血流与皮质醇分泌紧密耦合。在正常生理范围内，循环变量和肾上腺糖皮质激素功能的多周期、节律性组织源于独立的或仅弱耦合的振荡器，不一定是谐波相关的，表现出带有波动和间歇性的近周期性。
