Saenko E L, Yaropolov A I
A.N. Bakh Institute of Biochemistry, USSR Academy of Sciences, Moscow.
Biochem Int. 1990;20(2):215-25.
The interaction of CP with the red blood cell (RBC) receptor was shown to be a Ca2+ dependent process and be limited by CP binding on RBC membrane which is not followed by CP transport through the membrane into RBC. The nature of receptor interaction was determined. It was shown that receptors are formed by glycoproteins of PAS1 and PAS2 (glycoforin dimer and monomer, respectively) and terminal residues of sialic acid of these glycoproteins are important for CP reception. Receptor carbohydrate specificity was determined. Biantennary structure of CP molecule carbohydrate moiety which is bound to the receptor owing to 2 structural fragments: sialic acid terminal residues and the fragment including acetylglucosamine dimer and fucose, plays the main role in CP reception.
CP与红细胞（RBC）受体的相互作用被证明是一个依赖Ca2+的过程，并且受到CP在RBC膜上的结合限制，CP不会通过膜转运进入RBC。确定了受体相互作用的性质。结果表明，受体由PAS1和PAS2的糖蛋白形成（分别为糖蛋白二聚体和单体），这些糖蛋白的唾液酸末端残基对CP的接受很重要。确定了受体碳水化合物特异性。CP分子碳水化合物部分的双天线结构由于两个结构片段与受体结合：唾液酸末端残基以及包括乙酰葡糖胺二聚体和岩藻糖的片段，在CP接受中起主要作用。
