College of Medicine, University of Vermont, Burlington, VT 05405, USA.
Am J Prev Med. 2011 Jun;40(6):637-44. doi: 10.1016/j.amepre.2011.02.023.
Efficacy trials have generated interventions to improve health behaviors and biomarkers. However, these efforts have had limited impact on practice and policy. It is suggested that key methodologic and contextual issues have contributed to this state of affairs. Current research paradigms generally have not provided the answers needed for more probable and more rapid translation. A major shift is proposed to produce research with more rapid clinical, public health, and policy impact.
疗效试验已经产生了改善健康行为和生物标志物的干预措施。然而，这些努力对实践和政策的影响有限。有人认为，关键的方法学和背景问题促成了这种局面。当前的研究范式通常没有为更有可能和更迅速的转化提供所需的答案。建议进行重大转变，以产生更能迅速产生临床、公共卫生和政策影响的研究。
