Nagata Y, Hiraoka M, Akuta K, Abe M, Takahashi M, Jo S, Nishimura Y, Masunaga S, Fukuda M, Imura H
Department of Radiology, Faculty of Medicine, Kyoto University, Japan.
Cancer. 1990 Apr 15;65(8):1730-6. doi: 10.1002/1097-0142(19900415)65:8<1730::aid-cncr2820650812>3.0.co;2-d.
Inoperable malignant liver tumors have been treated by radiofrequency hyperthermia at Kyoto University Hospital since 1983. In this study, clinical hyperthermia for malignant liver tumor was evaluated for 67 tumors in which we could measure intratumor temperatures. Of the 67 tumors, 41 were hepatocellular carcinomas (HCC), six cholangiocarcinomas, and 20 metastatic tumors. Cholangiocarcinoma and metastatic tumors were more susceptible to this treatment than HCC. Of the three types of HCC, higher intratumor temperatures were achieved in the diffuse type than in the nodular or massive types. The minimum tumor temperature of HCC stayed below 40 degrees C in 46% of cases, especially in larger tumors. The local response rates (complete remission plus partial remission/all) were 28% and 11% for HCC and non-HCC, respectively, for thermochemotherapy; 86% and 33%, for thermoradiotherapy; and 33% and 89%, for thermotherapy with embolization. No apparent relationship was observed between the intratumor temperatures and local response rate.
自1983年以来，京都大学医院一直采用射频热疗治疗无法手术切除的恶性肝肿瘤。在本研究中，对67个可测量瘤内温度的恶性肝肿瘤进行了临床热疗评估。67个肿瘤中，41个为肝细胞癌（HCC），6个为胆管癌，20个为转移瘤。胆管癌和转移瘤比肝细胞癌对这种治疗更敏感。在三种类型的肝细胞癌中，弥漫型的瘤内温度高于结节型或巨块型。肝细胞癌的最低肿瘤温度在46%的病例中低于40℃，尤其是在较大的肿瘤中。热化疗时，肝细胞癌和非肝细胞癌的局部缓解率（完全缓解加部分缓解/所有病例）分别为28%和11%；热放疗时分别为86%和33%；热疗联合栓塞时分别为33%和89%。未观察到瘤内温度与局部缓解率之间有明显关系。
