Namba Ryoichi, Kanazawa Jun, Yamamoto Yusuke, Itou Shusaku, Nawa Takeshi
Dept. of Medicine, Hitachi General Hospital.
Gan To Kagaku Ryoho. 2011 May;38(5):807-10.
A 7 3-year-old man with angiosarcoma was treated with concurrent chemoradiotherapy, using docetaxel (25mg/m(2) weekly). While the size of the tumor reduced rapidly, fluid retention, considered as an adverse effect of docetaxel, appeared at the cumulative dose of 325mg/m(2). He required chest drainage for prolonged pleural effusion. Though fluid retention due to docetaxel is infrequently reported in Japan, it may lead to severe illness and require discontinuation of chemotherapy. When we administer docetaxel over a prolonged period, we should be aware of this adverse effect.
一名73岁的血管肉瘤男性患者接受了同步放化疗，使用多西他赛（25mg/m²每周）。虽然肿瘤大小迅速缩小，但在累积剂量达到325mg/m²时出现了液体潴留，这被认为是多西他赛的不良反应。他因长期胸腔积液需要进行胸腔引流。尽管在日本多西他赛导致的液体潴留报道较少，但它可能导致严重疾病并需要停止化疗。当我们长期使用多西他赛时，应该注意到这种不良反应。
