Laboratoire de Physiologie et d'Explorations Fonctionnelles, Unité de Formation et de Recherche en Sciences Médicales, Université de Cocody, Abidjan, Côte d'Ivoire.
Br J Haematol. 2011 Aug;154(3):398-407. doi: 10.1111/j.1365-2141.2011.08728.x. Epub 2011 May 14.
The levels and duration of physical activity that can be considered as completely safe in patients with sickle cell anaemia (SCA) is unknown. The present study compared the haemorheological and haematological profile, cell density distribution and basic biochemistry between a group of 17 patients with SCA and 21 healthy subjects before and after a 20 min duration submaximal cycling exercise at the same absolute workload. Blood was sampled at rest and 3 min after the end of exercise for measurement of biological parameters. Exercise did not affect the haematocrit and blood viscosity in the two groups. Plasma viscosity was not different between the two groups at rest and similarly increased with exercise. The proportion of intermediary dense cells (with density between 1·11 and 1·12 g/ml) decreased with exercise in the SCA group resulting in an increase in the proportion of red blood cells with a density >1·12 g/ml. No change was observed in the control group. The present study suggests that mild-moderate exercise is not very harmful for SCA patients. The haemorheological and haematological changes were very mild, except for the formation of dense cells but no clinically significant signs of medical complication were present in any of the patients.
在镰状细胞贫血（SCA）患者中，完全安全的身体活动水平和持续时间尚不清楚。本研究比较了 17 例 SCA 患者和 21 名健康受试者在相同的绝对工作负荷下进行 20 分钟亚最大循环运动前后的血液流变学和血液学特征、细胞密度分布和基本生物化学。在休息和运动结束后 3 分钟采血，以测量生物学参数。运动未影响两组的血细胞比容和血液黏度。两组在休息时的血浆黏度无差异，运动时均增加。SCA 组中间密细胞（密度在 1.11 至 1.12 g/ml 之间）的比例随运动而下降，导致密度>1.12 g/ml 的红细胞比例增加。对照组未见变化。本研究表明，轻度至中度运动对 SCA 患者的危害不大。血液流变学和血液学变化非常轻微，除了致密细胞的形成，但在任何患者中均未出现临床明显的并发症迹象。
