Department of Obstetrics and Gynaecology, University Hospital of Heraklion, Crete, Greece.
Eur J Obstet Gynecol Reprod Biol. 2011 Aug;157(2):166-8. doi: 10.1016/j.ejogrb.2011.03.029. Epub 2011 May 12.
To investigate the possible value of maternal serum concentration of insulin-like growth factor-I (IGF-I), IGF binding protein-1 (IGFBP-1) and IGFBP-3 in first-trimester screening for fetal aneuploidies.
Maternal serum concentrations of IGF-I, IGFBP-1 and IGFBP-3 at 11-13 weeks of gestation were measured and compared in 30 trisomy 21, 30 trisomy 18 and 120 euploid pregnancies.
The median multiple of the normal median (MoM) values of maternal serum IGF-I, IGFBP-1 and IGFBP-3 in trisomy 21, trisomy 18 and euploid pregnancies were not significantly different (IGF-I: 1.10, 1.14 and 1.0 MoM, respectively; IGFBP-1: 1.10, 1.01 and 1.0 MoM; IGFBP-3: 0.90, 1.16 and 0.98 MoM).
Measurement of maternal serum IGF-I, IGFBP-1 and IGFBP-3 at 11-13 weeks of gestation is unlikely to be useful in screening for trisomies 21 and 18.
探讨妊娠 11-13 周时母体血清胰岛素样生长因子-I（IGF-I）、IGF 结合蛋白-1（IGFBP-1）和 IGFBP-3 浓度在胎儿非整倍体筛查中的可能价值。
测量了 30 例 21 三体、30 例 18 三体和 120 例正常妊娠孕妇妊娠 11-13 周时母体血清 IGF-I、IGFBP-1 和 IGFBP-3 的浓度，并进行了比较。
21 三体、18 三体和正常妊娠孕妇母体血清 IGF-I、IGFBP-1 和 IGFBP-3 的中位数倍数（MoM）值中位数无显著差异（IGF-I：分别为 1.10、1.14 和 1.0 MoM；IGFBP-1：分别为 1.10、1.01 和 1.0 MoM；IGFBP-3：分别为 0.90、1.16 和 0.98 MoM）。
妊娠 11-13 周时母体血清 IGF-I、IGFBP-1 和 IGFBP-3 的测量值不太可能用于筛查 21 三体和 18 三体。
