Oldham M J, Phalen R F, Huxtable R F
Department of Community and Environmental Medicine, University of California, Irvine 92717.
Lab Anim Sci. 1990 Mar;40(2):186-91.
Because the ferret is being used increasingly in inhalation toxicology and lung physiology studies, it is necessary to better understand the airway structure of its tracheobronchial tree. Previously published information does not include dimensions of bronchi and bronchioles in either adult or growing ferrets. The airway structure of interest for calculating inhaled particle deposition patterns includes airway lengths, diameters and branching angles in each generation. Measurements of these dimensions were obtained for several selected airway paths on replica casts. Casts were made in-situ in four male litter mates age 14 hours, 9.5 days, 16.5 days and 56 days. These data demonstrate, that as with human lung growth, body length at a given age is a good predictor of airway lengths and diameters. Airway branch angles do not appear to change significantly during growth. Sufficient measurements were made to provide dimensions of a typical tracheobronchial pathway for this species. This pathway begins with the trachea and ends at the terminal bronchiole. The morphometric data were not sufficient to determine whether or not the number of tracheobronchial generations increase or decrease postnatally.
由于雪貂越来越多地被用于吸入毒理学和肺生理学研究，因此有必要更好地了解其气管支气管树的气道结构。先前发表的信息并未包含成年雪貂或生长中雪貂支气管和细支气管的尺寸。用于计算吸入颗粒沉积模式的气道结构包括每一代气道的长度、直径和分支角度。在复制铸型上对几条选定的气道路径进行了这些尺寸的测量。铸型是在4只年龄分别为14小时、9.5天、16.5天和56天的同窝雄性幼崽体内原位制作的。这些数据表明，与人类肺生长一样，特定年龄时的体长是气道长度和直径的良好预测指标。气道分支角度在生长过程中似乎没有显著变化。已进行了足够的测量，以提供该物种典型气管支气管路径的尺寸。该路径始于气管，止于终末细支气管。形态测量数据不足以确定气管支气管的代数在出生后是否增加或减少。
