State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, #32 Jiao Chang Dong Lu,Yunnan, PR China.
Neurosci Lett. 2011 Jul 8;498(2):133-7. doi: 10.1016/j.neulet.2011.04.076. Epub 2011 May 6.
The beta-adrenergic system has been suggested to be involved in novelty detection and memory modulation. The present study aimed to investigate the role of beta-adrenergic receptors on novelty-based spatial recognition memory and exploratory behavior in mice using Y-maze test and open-field respectively. Mice were injected with three doses of beta-adrenergic receptor antagonist, propranolol (2, 10 and 20 mg/kg) or saline at three different time points (15 min prior to training, immediately after training and 15 min before test). The results showed that higher doses of propranolol (10 and 20 mg/kg) given before the training trial impaired spatial recognition memory while those injected at other two time points did not. A detailed analysis of exploratory behavior in open-field showed that lower dose (2 mg/kg) of propranolol reduced exploratory behavior of mice. Our findings indicate that higher dose of propranolol can impair acquisition of spatial information in the Y-maze without altering locomotion, suggesting that the beta-adrenergic system may be involved in modulating memory processes at the time of learning.
β-肾上腺素能系统被认为参与了新奇感检测和记忆调节。本研究旨在使用 Y 迷宫测试和旷场测试分别研究β-肾上腺素受体在基于新奇感的空间识别记忆和探索行为中的作用。将三种剂量的β-肾上腺素受体拮抗剂普萘洛尔（2、10 和 20 mg/kg）或生理盐水分别在三个不同时间点（训练前 15 分钟、训练后立即和测试前 15 分钟）注射到小鼠体内。结果表明，在训练试验前给予较高剂量（10 和 20 mg/kg）的普萘洛尔会损害空间识别记忆，而在其他两个时间点注射则不会。对旷场中探索行为的详细分析表明，较低剂量（2 mg/kg）的普萘洛尔会减少小鼠的探索行为。我们的研究结果表明，较高剂量的普萘洛尔可以损害 Y 迷宫中空间信息的获取，而不改变运动能力，这表明β-肾上腺素能系统可能参与了学习时的记忆过程调节。
