帕金森病患者直立性低血压的患病率：系统评价和荟萃分析。
Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis.
机构信息
Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands.
出版信息
Parkinsonism Relat Disord. 2011 Dec;17(10):724-9. doi: 10.1016/j.parkreldis.2011.04.016. Epub 2011 May 14.
BACKGROUND
Although orthostatic hypotension (OH) is recognized as one of the main non-motor symptoms of Parkinson's disease (PD), there is inconsistent evidence about the prevalence of OH in PD. To estimate the prevalence of OH in PD more precisely we conducted a systematic review of the literature.
METHODS
From PubMed and Embase searches with predefined inclusion criteria, we identified studies published up till December 2009. Prevalence numbers from studies were pooled using a non-linear random-effects meta-analysis.
RESULTS
We found 25 studies from which the prevalence of OH could be calculated. The pooled estimate of the point prevalence of OH in PD was 30.1% (95% CI: 22.9% to 38.4%). We found a large statistical heterogeneity between studies which could not be reduced by several subgroup analyses.
CONCLUSIONS
The estimated prevalence of OH in PD is 30%. However, due to the large heterogeneity between studies this pooled estimate should be interpreted with caution. More data from unselected population-based cohorts are needed.
背景
虽然直立性低血压（OH）被认为是帕金森病（PD）的主要非运动症状之一，但 OH 在 PD 中的患病率存在不一致的证据。为了更准确地估计 PD 中 OH 的患病率，我们对文献进行了系统评价。
方法
根据预定义的纳入标准，我们从 PubMed 和 Embase 搜索中确定了截至 2009 年 12 月发表的研究。使用非线性随机效应荟萃分析对来自研究的患病率数据进行了汇总。
结果
我们从 25 项研究中计算出 OH 的患病率。PD 中 OH 的点患病率的汇总估计值为 30.1%（95%CI：22.9%至 38.4%）。我们发现研究之间存在很大的统计学异质性，无法通过几种亚组分析来减少。
结论
PD 中 OH 的估计患病率为 30%。然而，由于研究之间存在很大的异质性，因此应谨慎解释此汇总估计值。需要更多来自非选择性基于人群的队列的数据。
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