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[蛋白结合型维生素B₁₂吸收不良所致大细胞性贫血、多发性神经病及后索疾病]

[Macrocytosis, polyneuropathy and posterior column disorders caused by malabsorption of protein-bound vitamin B12].

作者信息

Mazure A, Bieger R, Lambregts P C, Wiarda K S

机构信息

Afd. Interne Geneeskunde, Bronovo Ziekenhuis, Gravenhage.

出版信息

Ned Tijdschr Geneeskd. 1990 Mar 31;134(13):660-2.

PMID:2157168
Abstract

This case report concerns a patient with a vitamin B12 deficiency and a normal Schilling test, who had macrocytosis of many years' duration and finally polyneuropathy. All known causes of a vitamin B12 deficiency were excluded. When the Schilling test was performed with egg consumption, excretion of vitamin B12 was clearly diminished. It appears highly likely that this vitamin B12 deficiency developed as a result of malabsorption of protein-bound vitamin B12.

摘要

本病例报告涉及一名维生素B12缺乏且希林试验结果正常的患者,该患者多年来一直存在大细胞性贫血,最终发展为多发性神经病。所有已知的维生素B12缺乏病因均被排除。当在食用鸡蛋的情况下进行希林试验时,维生素B12的排泄明显减少。极有可能是由于与蛋白质结合的维生素B12吸收不良导致了这种维生素B12缺乏。

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