Austin-Seymour M, Urie M, Munzenrider J, Willett C, Goitein M, Verhey L, Gentry R, McNulty P, Koehler A, Suit H
Department of Radiation Medicine, Massachusetts General Hospital, Boston 02114.
Radiother Oncol. 1990 Jan;17(1):29-35. doi: 10.1016/0167-8140(90)90046-y.
Protons have a finite range in tissue and can provide a better concentration of radiation dose in the tumor than conventional X-rays in certain situations. The development of optimized treatment plans for X-rays and protons followed by a comparative evaluation is one method of selecting tumor sites best suited for proton treatment. The preliminary results of comparative treatment planning for base of skull tumors and carcinoma of the prostate are discussed. These comparisons suggest a clinical gain for proton treatment of tumors in these locations. The clinical experience with fractionated proton treatment of several tumor sites is also discussed. The results of high dose proton treatment of chordomas and low grade chondrosarcomas of the base of skull is particularly promising: an actuarial 5-year local control of 78% has been obtained in 50 patients followed for a minimum of 22 months.
质子在组织中有一定射程，在某些情况下，相较于传统X射线，质子能在肿瘤部位实现更好的辐射剂量集中。制定X射线和质子的优化治疗计划并进行对比评估，是选择最适合质子治疗的肿瘤部位的一种方法。本文讨论了颅底肿瘤和前列腺癌对比治疗计划的初步结果。这些对比表明质子治疗这些部位的肿瘤具有临床优势。还讨论了多个肿瘤部位的质子分次治疗的临床经验。颅底脊索瘤和低级别软骨肉瘤的高剂量质子治疗结果尤其令人鼓舞：50例患者接受治疗，随访至少22个月，精算5年局部控制率达78%。
