Rovelli Francesca, Mercuri Santo Raffaele, Naldi Luigi
Recenti Prog Med. 2011 Mar;102(3):126-33. doi: 10.1701/608.7069.
Seborrheic dermatitis is a chronic relapsing inflammatory skin condition characterized by scaling and poorly defined erythematous patches in areas rich in sebaceous glands. It is one of the most frequent skin disorders and may be socially embarrassing. Fungi of the genus Malassezia, lipid-dependent, ubiquitous skin residents, play a pathogenic role. Topical antifungal agents (e.g., ketoconazole) are the mainstay of treatment, and if used intermittently they can maintain remission. The vehicle itself may also play a relevant role. Improvements in diagnostic criteria, severity measures and outcome variables are needed to better design clinical trials and inform clinical practice.
脂溢性皮炎是一种慢性复发性炎症性皮肤病,其特征是皮脂腺丰富区域出现脱屑和边界不清的红斑。它是最常见的皮肤疾病之一,可能会给患者带来社交困扰。马拉色菌属真菌是一种依赖脂质、广泛存在于皮肤的常驻菌,具有致病作用。外用抗真菌药物(如酮康唑)是主要的治疗方法,间歇性使用可维持病情缓解。药物载体本身也可能发挥相关作用。需要改进诊断标准、严重程度评估方法和结局变量,以便更好地设计临床试验并为临床实践提供依据。