Basak R B, Narchi H, Bakir M, Joshi S, Conca W
Department of Paediatrics, Al Ain Hospital, Al Ain, United Arab Emirates, Dubai.
Indian J Dermatol. 2011 Jan;56(1):84-6. doi: 10.4103/0019-5154.77561.
Churg-Strauss Syndrome (CSS) is rare in children. It consists of a small- and medium-sized vessel vasculitis, with skin and peripheral nerve involvement. It is characterized by eosinophilia, extravascular necrotizing granuloma, and eosinophilic infiltration of multiple organs particularly the lungs, but may also involve the gastrointestinal tract, the heart, and the kidneys. The condition is usually associated with a preceding history of asthma or allergic sinusitis. It has rarely been reported in children, where most of the cases had pre-existing asthma, allergic rhinitis, or atopic disease. We report a 10-year-old Arab girl proven to have CSS, with no history of asthma or allergic rhinitis, who presented with tender cutaneous nodules of lower extremities, foot drop, and peripheral eosinophilia, without any clinical respiratory symptoms or signs.
变应性肉芽肿性血管炎（CSS）在儿童中较为罕见。它是一种中小血管血管炎，伴有皮肤和周围神经受累。其特征为嗜酸性粒细胞增多、血管外坏死性肉芽肿以及多个器官尤其是肺部的嗜酸性粒细胞浸润，但也可能累及胃肠道、心脏和肾脏。这种疾病通常与先前的哮喘或变应性鼻窦炎病史相关。儿童病例报道很少，其中大多数病例有既往哮喘、变应性鼻炎或特应性疾病史。我们报告一名10岁阿拉伯女孩，经证实患有CSS，无哮喘或变应性鼻炎病史，表现为下肢压痛性皮肤结节、足下垂和外周血嗜酸性粒细胞增多，无任何临床呼吸道症状或体征。
