Erb M Kelley, Chen Debbie K, Sassaroli Angelo, Fantini Sergio, Bergethon Peter R
Boston University School of Medicine, Boston MA, USA 02118.
Proc SPIE Int Soc Opt Eng. 2011 Jan 23;7896(1). doi: 10.1117/12.875145.
We have previously reported an optical response in human subjects occurring at 100 ms following electrical stimulation of peripheral nerves. In the present study, an animal model has been created to directly investigate the myogenic components of the signal. In addition, experiments have been performed in human subjects to investigate the signal's neuroanatomical specificity, sensitivity to muscle motion, and spatial and spectral features. The results of this work suggest that the observed optical signal derives from stimulus-induced motion associated with muscle contraction and likely contains myological information of clinical value.
我们之前报道过，在对人体受试者的外周神经进行电刺激后100毫秒会出现一种光学反应。在本研究中，已建立了一种动物模型来直接研究该信号的肌源性成分。此外，还对人体受试者进行了实验，以研究该信号的神经解剖学特异性、对肌肉运动的敏感性以及空间和光谱特征。这项工作的结果表明，观察到的光学信号源自与肌肉收缩相关的刺激诱发运动，并且可能包含具有临床价值的肌学信息。
