• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一个关于DNA非整倍体起源与进化的模型。

A model on the origin and evolution of DNA aneuploidy.

作者信息

Giaretti W

出版信息

Int J Oncol. 1993 Feb;2(2):165-71.

PMID:21573531
Abstract

A model on the origin and evolution of DNA aneuploidy based on a postulated mechanism of DNA asymmetrical cell division is presented. Asymmetry in cell division would be at the origin of hypodiploid cells in the near-diploid region. Tetraploidization of a hypodiploid cell would be one of the main routes by which advanced tumors may evolve to aneuploidy in the near-triploid region. The model is supported by nuclear DNA content data obtained by high resolution flow cytometry from fresh/frozen material during the colorectal tumor progression.

摘要

本文提出了一种基于假定的DNA不对称细胞分裂机制的DNA非整倍体起源与进化模型。细胞分裂的不对称性可能是近二倍体区域中次二倍体细胞的起源。次二倍体细胞的四倍体化可能是晚期肿瘤在近三倍体区域演变为非整倍体的主要途径之一。该模型得到了通过高分辨率流式细胞术从结直肠肿瘤进展过程中的新鲜/冷冻材料获得的核DNA含量数据的支持。

相似文献

1
A model on the origin and evolution of DNA aneuploidy.一个关于DNA非整倍体起源与进化的模型。
Int J Oncol. 1993 Feb;2(2):165-71.
2
A model of DNA aneuploidization and evolution in colorectal cancer.一种结直肠癌中DNA非整倍体化与进化的模型。
Lab Invest. 1994 Dec;71(6):904-10.
3
Intratumoral patterns of clonal evolution in meningiomas as defined by multicolor interphase fluorescence in situ hybridization (FISH): is there a relationship between histopathologically benign and atypical/anaplastic lesions?通过多色间期荧光原位杂交（FISH）定义的脑膜瘤瘤内克隆进化模式：组织病理学上的良性病变与非典型/间变性病变之间是否存在关联？
J Mol Diagn. 2004 Nov;6(4):316-25. doi: 10.1016/S1525-1578(10)60527-2.
4
DNA aneuploidy in Hodgkin's disease. A multiparameter flow-cytometric analysis with cytologic correlation.霍奇金病中的DNA非整倍体。一项与细胞学相关的多参数流式细胞术分析。
Am J Pathol. 1987 Sep;128(3):573-82.
5
Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy.结直肠癌中K-ras2突变的肿瘤内异质性：与DNA非整倍体程度的关联
Am J Pathol. 1996 Jul;149(1):237-45.
6
Prognostic indicators including DNA histogram type, receptor content, and staging related to human breast cancer patient survival.包括DNA直方图类型、受体含量以及分期在内的预后指标与人类乳腺癌患者的生存情况相关。
Cancer Res. 1984 Sep;44(9):4187-96.
7
Intratumor heterogeneity of chromosome 1, 7, 17, and 18 aneusomies obtained by FISH and association with flow cytometric DNA index in human colorectal adenocarcinomas.通过荧光原位杂交（FISH）获得的人结肠腺癌中1号、7号、17号和18号染色体非整倍体的肿瘤内异质性及其与流式细胞术DNA指数的相关性
Cytometry. 1999 Apr 1;35(4):369-75.
8
Proliferative characteristics and ploidy of human brain tumors by DNA flow cytometry.
Basic Appl Histochem. 1986;30(2):175-80.
9
DNA ploidy and proliferation heterogeneity in human prostate cancers.人类前列腺癌中的DNA倍体与增殖异质性
Cytometry. 1995 Sep 1;21(1):30-9. doi: 10.1002/cyto.990210108.
10
DNA ploidy status and DNA content instability within single tumors in renal cell carcinoma.肾细胞癌单个肿瘤内的DNA倍体状态和DNA含量不稳定性
Cytometry. 1993;14(5):559-64. doi: 10.1002/cyto.990140516.

引用本文的文献

1
Nuclear DNA-Content in Mesenchymal Lesions in Dogs: Its Value as Marker of Malignancy and Extent of Genomic Instability.犬类间叶性病变中的核 DNA 含量：作为恶性标志物和基因组不稳定性程度的价值。
Cancers (Basel). 2012 Dec 3;4(4):1300-17. doi: 10.3390/cancers4041300.
2
Uncoupling of the order of the S and M phases: effects of staurosporine on human cell cycle kinases.S期和M期顺序的解偶联：星形孢菌素对人细胞周期激酶的影响。
Cell Prolif. 1997 May;30(5):197-218. doi: 10.1046/j.1365-2184.1997.00087.x.
3
DNA aneuploidy is an independent factor of poor prognosis in pancreatic and peripancreatic cancer.
DNA非整倍体是胰腺和胰腺周围癌预后不良的独立因素。
Int J Pancreatol. 1993 Aug;14(1):21-8. doi: 10.1007/BF02795226.
4
Near-diploid transitional cell carcinoma: a preliminary report.近二倍体移行细胞癌：初步报告。
Int Urol Nephrol. 1994;26(4):423-30. doi: 10.1007/BF02768013.