Pcna expression and ag-nor score in breast-cancer - correlation with clinicopathological variables and patient survival.

We evaluated the relationships among proliferative cell nuclear antigen (PCNA) expression, nucleolar organizer region (Ag-NOR) score and clinicopathologic variables, and their prognostic value, in 95 patients with breast cancer. PCNA expression was not found to be significantly associated with Ag-NOR score or with established clinicopathologic prognostic factors with the exception of histologic grade. Moreover, univariate and multivariate analyses showed that PCNA expression did not appear to be a significant prognostic factor, while Ag-NOR score was a significant prognostic factor only by univariate analysis. We therefore, concluded that PCNA expression may not be a useful prognostic factor in breast cancer.