Rygaard K, Klausen B, Nakamura T, Spangthomsen M
KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN.
Int J Oncol. 1993 Jun;2(6):991-6. doi: 10.3892/ijo.2.6.991.
Expression of the c-met proto-oncogene is common iii small cell lung cancer (SCLC) cell lines. The product of this proto-oncogene is the receptor for hepatocyte growth factor (HGF), also known as scatter factor (SF) and hepatopoietin A. We examined the effect of HGF/SF on 8 SCLC cell lines of which six expressed c-Met and 2 control cell lines did not. The effect was monitored by growth curves, in vitro migration in Boyden chambers. and by examination of morphology. Three cell lines responded in one or more of the following ways: Growth inhibition, morphological alterations. and increased migration in Boyden chambers. We conclude that functional c-Met receptors are frequently expressed in SCLC and may contribute to the behaviour of this tumour type.
c-met原癌基因在小细胞肺癌（SCLC）细胞系中普遍表达。该原癌基因的产物是肝细胞生长因子（HGF）的受体，HGF也被称为分散因子（SF）和肝细胞生成素A。我们检测了HGF/SF对8种SCLC细胞系的影响，其中6种表达c-Met，2种对照细胞系不表达。通过生长曲线、在Boyden小室中的体外迁移以及形态学检查来监测其效果。三种细胞系以以下一种或多种方式作出反应：生长抑制、形态改变以及在Boyden小室中迁移增加。我们得出结论，功能性c-Met受体在SCLC中经常表达，可能有助于这种肿瘤类型的生物学行为。
