Department of Electronic Engineering, Information School, Yunnan University, Kunming, 650091, China.
Sci China Life Sci. 2011 May;54(5):459-65. doi: 10.1007/s11427-011-4170-1. Epub 2011 May 15.
Baclofen is a selective gamma-aminobutyric acid (GABA) type B agonist that may have important medicinal uses, such as in analgesics and drug addiction treatment. In addition, evidence is accumulating that suggests GABAergic-mediated neurotransmission is altered during aging. This study investigated whether baclofen administration (5 mg kg(-1)) induces differential effects on cortical electrical activity with age. Electroencephalograms (EEGs) were recorded from young (3-4 months) and aged (15-17 months) rats, and both the absolute and relative powers in five frequency bands (delta: 2-4 Hz; theta: 4-8 Hz; alpha: 8-12 Hz; beta: 12-20 Hz; gamma: 20-100 Hz) were analyzed. Before administration of baclofen, we found that the EEG relative power in the beta band was higher in the aged than that in the young rats. After administration of baclofen, there was a slower increase in the relative power in the delta band in the aged than that in the young rats. Moreover, there was no significant difference between the two age groups in absolute power in any frequency band. These findings indicate that baclofen treatment appears to differentially modify cortical EEG activity as a function of age. Our data further elucidate the relationship between GABA(B) receptor-mediated neurotransmission and aging.
巴氯芬是一种选择性γ-氨基丁酸（GABA）B 型激动剂，可能具有重要的药用价值，例如在止痛药和药物成瘾治疗中。此外，越来越多的证据表明，GABA 能介导的神经传递在衰老过程中发生改变。本研究探讨了巴氯芬给药（5mgkg-1）是否会随着年龄的增长而对皮质电活动产生不同的影响。从年轻（3-4 个月）和年老（15-17 个月）大鼠中记录脑电图（EEG），并分析五个频带（δ：2-4Hz；θ：4-8Hz；α：8-12Hz；β：12-20Hz；γ：20-100Hz）中的绝对和相对功率。在给予巴氯芬之前，我们发现年老大鼠的β频带的 EEG 相对功率高于年轻大鼠。给予巴氯芬后，年老大鼠的 δ 频带的相对功率增加较慢。此外，两个年龄组在任何频带的绝对功率均无显著差异。这些发现表明，巴氯芬治疗似乎会随着年龄的增长而对皮质脑电图活动产生不同的影响。我们的数据进一步阐明了 GABA（B）受体介导的神经传递与衰老之间的关系。
