Graduate School of Systems Life Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka, 812-8581, Japan.
Protein J. 2011 Apr;30(4):290-7. doi: 10.1007/s10930-011-9332-2.
The frequencies of amino acid residues are known to be biased at both terminal regions of amino acid sequences deduced from bacterial genomic DNA. To investigate whether or not the features of biases of amino acid residues at the terminal regions are related to the bacterial phylogeny, we calculated the normalized amino acid compositions at both terminal regions, and used these compositions to classify 144 bacteria by hierarchical clustering analysis. Our results showed that most of these bacteria were classified into taxonomic classes by the hierarchical clustering analysis that was based on the normalized amino acid compositions at the N-terminal region. Therefore, we concluded that the features of biases of the N-terminal amino acid residues were related to the bacterial phylogeny.
已知从细菌基因组 DNA 推导的氨基酸序列的两端区域的氨基酸残基频率存在偏向性。为了研究氨基酸残基在末端区域的偏向性特征是否与细菌系统发育有关，我们计算了两个末端区域的归一化氨基酸组成，并使用这些组成通过层次聚类分析对 144 种细菌进行分类。结果表明，基于 N-末端区域归一化氨基酸组成的层次聚类分析可以将大多数细菌归入分类类别。因此，我们得出结论，N-末端氨基酸残基的偏向性特征与细菌系统发育有关。
