Romantsov M G, Goryacheva L G, Bekhtereva M K, Sologub T V, Kovalenko A L
Antibiot Khimioter. 2010;55(11-12):39-51.
The authors' findings and literature data on the pharmacotherapeut efficacy of cycloferon, an interferon inductor (immunomodulators) are described. The drug effect in the treatment of various socially significant children' diseases, including acute respiratory tract viral infection, bronchial asthma, allergic conditions with infection protection disturbances, mycoplasmic infection, bronchopulmonary complications of acute respiratory tract viral infection with low intensity of free radical oxidation is indicated. The use of cycloferon at the background of vaccination was shown to provide inhibition of the autoimmune processes causing postvaccinal complications in frequently ill children. The results of the use of cycloferon in the treatment of gastrointestinal tract and intestinal infections of both the viral and bacterial genesis are discussed. Cycferon is recommended to be used for correction of the intestine dysbiosis (the microflora level came to normal in 95% of the children). The use of the drug in surgical pathology and in particular in appendicular peritonitis for decreasing the postoperative complications and correction of the immune disturbances due to chronic viral hepatitis C and B in children under the complex therapy is described. The cycloferon safety and efficacy were confirmed by the postmarketing randomized trials.
本文描述了作者关于干扰素诱导剂（免疫调节剂）环孢素的药物治疗效果的研究结果以及文献数据。指出了该药物在治疗各种具有社会意义的儿童疾病中的作用，包括急性呼吸道病毒感染、支气管哮喘、伴有感染防护障碍的过敏性疾病、支原体感染、自由基氧化强度低的急性呼吸道病毒感染的支气管肺并发症。研究表明，在接种疫苗的背景下使用环孢素可抑制经常生病儿童中导致疫苗接种后并发症的自身免疫过程。文中还讨论了环孢素在治疗胃肠道和肠道病毒及细菌感染性疾病中的应用结果。建议使用环孢素纠正肠道菌群失调（95%的儿童微生物群水平恢复正常）。描述了该药物在外科病理学中的应用，特别是在阑尾腹膜炎中，用于减少术后并发症以及在综合治疗下纠正儿童慢性丙型和乙型病毒性肝炎引起的免疫紊乱。环孢素的安全性和有效性在上市后随机试验中得到了证实。
