Department of Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
Ren Fail. 2011;33(5):506-11. doi: 10.3109/0886022X.2011.576794.
Adiponectin plays an important role in the regulation of body weight, insulin sensitivity, lipid metabolism, and the inflammatory response. Adiponectin is elevated in hemodialysis patients. We investigated the association between altered serum adiponectin levels and the nutritional-inflammation status of hemodialysis patients. Forty-four hemodialysis patients (21 men and 23 women; mean age 53.9 ± 9.2 years) were enrolled and 32 healthy volunteers were included as the control group. Serum adiponectin was measured using a commercial radioimmunoassay kit. Serum albumin, cholesterol, triglyceride, high-sensitivity C-reactive protein, urea, creatinine, transferrin, lean body mass, fat mass, body mass index (BMI), the subjective global assessment (SGA) score, and the malnutrition-inflammation score (MIS) were measured in all patients. Adiponectin levels were significantly elevated in the hemodialysis patients compared with the healthy subjects (24.8 ± 10.4 μg/mL and 6.8 ± 4.2 μg/mL, respectively, p < 0.0001). Serum adiponectin correlated positively with SGA (r = 0.47) and MIS (r = 0.38), and negatively with BMI (r = -0.34), triglyceride (r = -0.53), and glucose levels (r = -0.42). Serum adiponectin levels were significantly higher in malnourished patients than in well-nourished patients when assessed with SGA (20.5 ± 10.4 μg/mL and 29.0 ± 8.7 μg/mL, respectively, p = 0.005). In conclusion, serum adiponectin levels reflect the nutritional-inflammation status of hemodialysis patients. Adiponectin may also be associated with insulin resistance, dyslipidemia, and the inflammatory response in these patients.
脂联素在调节体重、胰岛素敏感性、脂代谢和炎症反应方面发挥着重要作用。在血液透析患者中，脂联素水平升高。我们研究了血清脂联素水平的变化与血液透析患者营养-炎症状态之间的关系。共纳入 44 例血液透析患者（男 21 例，女 23 例；平均年龄 53.9±9.2 岁），并纳入 32 例健康志愿者作为对照组。采用商业放射免疫试剂盒测定血清脂联素水平。所有患者均测定血清白蛋白、胆固醇、甘油三酯、高敏 C 反应蛋白、尿素、肌酐、转铁蛋白、瘦体重、体脂量、体重指数（BMI）、主观全面评估（SGA）评分和营养不良-炎症评分（MIS）。与健康对照组相比，血液透析患者的血清脂联素水平显著升高（分别为 24.8±10.4μg/ml 和 6.8±4.2μg/ml，p<0.0001）。血清脂联素与 SGA（r=0.47）和 MIS（r=0.38）呈正相关，与 BMI（r=-0.34）、甘油三酯（r=-0.53）和血糖水平（r=-0.42）呈负相关。SGA 评估显示，营养不良患者的血清脂联素水平显著高于营养良好患者（分别为 20.5±10.4μg/ml 和 29.0±8.7μg/ml，p=0.005）。结论：血清脂联素水平反映了血液透析患者的营养-炎症状态。脂联素可能与这些患者的胰岛素抵抗、血脂异常和炎症反应有关。
