Cao Ka-Jia, Zhang Ai-Lan, Ma Wen-Juan, Huang Pei-Yu, Luo Dong-Hua, Xia Wei-Xiong
Department of Nasopharyngeal Cancer, Cancer Center, Sun Yat-sen University, State Key Laboratory of Oncology in South China, Guangzhou 510060, China. caokj@ sysucc.org.cn
Zhonghua Zhong Liu Za Zhi. 2011 Jan;33(1):50-2.
To compare the efficacy and side effects of nedaplatin plus 5-fluorouracil (5-Fu) and cisplatin plus 5-Fu for treatment of stage III-IVa nasopharyngeal carcinoma (NPC).
A total of 100 patients with NPC proved by histopathology were divided into nedaplatin plus 5-Fu group (NF group) and cisplatin plus 5-Fu group (PF group), 50 cases in each group. NF group: nedaplatin 30 mg/m(2), d1-d3, 5-Fu 500 mg/m(2) d1-d5, repeated every 3 weeks for 2 cycles. PF group: cisplatin 30 mg/m(2) d1-d3, 5-Fu 500 mg/m(2) d1-d5, repeated every 3 weeks for 2 cycles. χ(2) test was used to compare the efficacy and side-effects of the two groups.
All the 100 cases were evaluable and their clinical data in the two groups were comparable. Six patients with complete response were observed, 3 cases in NF group and 3 in PF group. The overall response rates were 86.0% in NF group and 84.0% in PF group, with no significant difference (χ(2) = 0.078, P = 0.779). The rates of leukocytopenia, thrombocytopenia, impairment of hepatic and renal function were similar whereas more patients in the PF group than in the NF group suffered from nausea and vomiting (88.0% vs. 56.0%, P = 0.000).
Nedaplatin plus 5-Fu is an effective treatment regimen for NPC. When compared with PF regimen, the response rate is similar. However, NF regimen shows a significant superiority in reducing nausea and vomiting.
比较奈达铂联合5-氟尿嘧啶（5-Fu）与顺铂联合5-Fu治疗Ⅲ-Ⅳa期鼻咽癌（NPC）的疗效及副作用。
将100例经组织病理学证实的NPC患者分为奈达铂联合5-Fu组（NF组）和顺铂联合5-Fu组（PF组），每组50例。NF组：奈达铂30mg/m²，第1 - 3天，5-Fu 500mg/m²，第1 - 5天，每3周重复，共2个周期。PF组：顺铂30mg/m²，第1 - 3天，5-Fu 500mg/m²，第1 - 5天，每3周重复，共2个周期。采用χ²检验比较两组的疗效和副作用。
100例患者均可评价，两组临床资料具有可比性。观察到6例完全缓解患者，NF组3例，PF组3例。NF组总有效率为86.0%，PF组为84.0%，差异无统计学意义（χ² = 0.078，P = 0.779）。白细胞减少、血小板减少、肝肾功能损害发生率相似，但PF组恶心呕吐患者多于NF组（88.0%对56.0%，P = 0.000）。
奈达铂联合5-Fu是治疗NPC的有效方案。与PF方案相比，有效率相似。然而，NF方案在减轻恶心呕吐方面具有显著优势。
