Hartong R, Wiersinga W M, Plomp T A
Department of Endocrinology, University of Amsterdam, The Netherlands.
Horm Metab Res. 1990 Feb;22(2):85-9. doi: 10.1055/s-2007-1004857.
The effect of injection of 1 mg/kg triiodothyronine on cardiac beta-adrenoceptor state was investigated in hypothyroid rats and compared to the effect in hypothyroid rats pretreated with amiodarone (200 mg/kg/day for 8 days). The Kd values of iodocyanopindolol binding to the beta-receptors were not influenced by either T3 injection or by amiodarone treatment. In the absence of amiodarone, injection of triiodothyronine resulted in a small decrease in receptor density at 6 hr, followed by an increase at 24 hr. Rats treated with amiodarone showed a similar response pattern to hormone injection (i. e. a small decrease in receptor density at 6 hr, followed by an increase at 24 hr), but the amplitude of the response was significantly reduced. Moreover, in vehicle injected rats amiodarone treatment resulted in a decrease in receptor density when rats were mildly hypothyroid, but not when rats were severely hypothyroid. It is concluded that amiodarone interferes (directly or indirectly) with thyroid hormone action in the heart.
研究了在甲状腺功能减退大鼠中注射1mg/kg三碘甲状腺原氨酸对心脏β-肾上腺素能受体状态的影响，并与用胺碘酮预处理（200mg/kg/天，共8天）的甲状腺功能减退大鼠的效果进行了比较。碘氰吲哚洛尔与β-受体结合的解离常数（Kd值）不受三碘甲状腺原氨酸注射或胺碘酮治疗的影响。在没有胺碘酮的情况下，注射三碘甲状腺原氨酸在6小时时导致受体密度略有下降，随后在24小时时增加。用胺碘酮治疗的大鼠对激素注射表现出类似的反应模式（即6小时时受体密度略有下降，随后在24小时时增加），但反应幅度明显降低。此外，在注射溶剂的大鼠中，当大鼠轻度甲状腺功能减退时，胺碘酮治疗导致受体密度降低，但在大鼠严重甲状腺功能减退时则不然。得出的结论是，胺碘酮（直接或间接）干扰心脏中甲状腺激素的作用。
