Mikosch Peter
2. Medizinische Abteilung, Landeskrankenhaus Klagenfurt, St. Veiterstrasse 47, Klagenfurt, Austria.
Wien Med Wochenschr. 2008;158(1-2):29-35. doi: 10.1007/s10354-007-0475-x.
Amiodarone is a frequently used antiarrhythmic drug with a high antiarrhythmic potency. However, beside its antiarrhythmic effects Amiodarone also reveals a variety of adverse effects and drug-related complications. The affected organs include the eyes, skin, lungs, nervous system, liver, gastrointestinal tract and the thyroid. The thyroid is one of the most frequently affected organs by Amiodarone. An altered hormone equilibrium always occurs and has to be distinguished from Amiodarone induced hyperthyroidism and hypothyroidism. The differentiation of these states frequently causes problems and may even be a diagnostic and therapeutic challenge in certain cases. The article gives an overview on the interactions between Amiodarone and the thyroid, the diagnostic and therapeutic options and management strategies of patient on Amiodarone therapy in the view of thyroid function.
胺碘酮是一种常用的抗心律失常药物，具有很高的抗心律失常效力。然而，除了其抗心律失常作用外，胺碘酮还会出现多种不良反应和药物相关并发症。受影响的器官包括眼睛、皮肤、肺、神经系统、肝脏、胃肠道和甲状腺。甲状腺是胺碘酮最常累及的器官之一。激素平衡总是会发生改变，必须与胺碘酮所致的甲状腺功能亢进和甲状腺功能减退相区分。这些状态的鉴别常常会引发问题，在某些情况下甚至可能是诊断和治疗上的挑战。本文从甲状腺功能的角度，概述了胺碘酮与甲状腺之间的相互作用、诊断和治疗选择以及胺碘酮治疗患者的管理策略。
