Department of Mental Health, Seoul National Hospital, Seoul, Republic of Korea.
Neuropsychobiology. 2011;64(1):1-8. doi: 10.1159/000322144. Epub 2011 May 14.
The current study aimed to investigate the interaction between the serotonin 1A receptor gene (HTR1A) C-1019G polymorphism and recent negative life stressors on depression in a Korean community sample. The HTR1A C-1019G polymorphism was genotyped in 416 community-dwelling Koreans (156 males, 260 females; 44.37 ± 14.67 years old). Lifetime and current major depressive episodes were diagnosed using the Structured Clinical Interview for DSM-IV. The Center for Epidemiological Studies for Depression Scale (CES-D) was self-applied and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. The results indicated that there were significant interactions between the C-1019G polymorphism and negative life stressors on CES-D scores (p = 0.02) as well as on current major depressive episodes (p = 0.002), but not on past major depressive episodes. G carriers alone had higher CES-D scores and more frequently experienced major depressive episodes after stressors. The interaction between the C-1019G polymorphism in HTR1A and recent negative life stressors accounted for current major depressive episodes and depressive symptoms. Our findings suggest that people with this gene variant may be more susceptible to developing depression especially after negative life stressors.
本研究旨在探讨韩国社区样本中，5-羟色胺 1A 受体基因（HTR1A）C-1019G 多态性与近期负性生活应激源对抑郁的交互作用。对 416 名社区居民（男性 156 名，女性 260 名；年龄 44.37±14.67 岁）进行 HTR1A C-1019G 多态性基因分型。使用 DSM-IV 结构临床访谈对终生和当前重性抑郁发作进行诊断。采用流行病学研究中心抑郁量表（CES-D）进行自我评估，并进行面对面访谈，调查过去 6 个月内的负性生活应激源。结果表明，C-1019G 多态性与负性生活应激源对 CES-D 评分（p=0.02）和当前重性抑郁发作（p=0.002）存在显著交互作用，但与过去重性抑郁发作无交互作用。仅 G 携带者在应激后 CES-D 评分更高，且更常发生重性抑郁发作。HTR1A 中的 C-1019G 多态性与近期负性生活应激源的相互作用导致了当前的重性抑郁发作和抑郁症状。我们的研究结果表明，具有这种基因变异的人可能更容易患上抑郁症，尤其是在经历负性生活应激源之后。
