Bohl Stephan R, Pircher Andreas, Hilbe Wolfgang
Medical University Innsbruck, Department of Internal Medicine V, Haematology and Oncology, Innsbruck, Austria.
Onkologie. 2011;34(5):269-74. doi: 10.1159/000327815. Epub 2011 Apr 26.
With the cancer stem cell (CSC) hypothesis many questions regarding cancer development and drug resistance can be answered more coherently than with the traditional model based on clonal evolution. CSCs are a small subset of cancer cells within the tumour that show stem cell characteristics like self-renewal, the capability to develop into multiple lineages and the potential to proliferate extensively, and are characterised by a typical profile of different markers like CD44 and CD133. In the CSC model, the role of embryonic pathways like Wnt, Hedgehog and Notch is of special interest. This review presents current scientific knowledge on this topic and discusses the potential role of CSC in the resistance against chemotherapy or radiation and presents challenging options for therapeutic interventions.
基于癌症干细胞（CSC）假说，许多关于癌症发展和耐药性的问题，相较于基于克隆进化的传统模型，能够得到更连贯一致的解答。癌症干细胞是肿瘤内一小部分具有干细胞特征的癌细胞，如自我更新能力、分化为多种细胞谱系的能力以及广泛增殖的潜力，其特征还表现为具有如CD44和CD133等不同标志物的典型表达谱。在癌症干细胞模型中，Wnt、Hedgehog和Notch等胚胎信号通路的作用备受关注。本综述介绍了关于这一主题的当前科学知识，并讨论了癌症干细胞在化疗或放疗耐药性中的潜在作用，还提出了具有挑战性的治疗干预方案。
