Kopper László, Hajdú Melinda
I. sz. Patológiai és Kísérleti Rákkutató Intézet, Semmelweis Egyetem, Altalános Orvostudományi Kar, Budapest, Hungary.
Magy Onkol. 2006;50(2):101-6. Epub 2006 Aug 4.
More and more evidence support that tumors arise from somatic stem cells or from cells, either progenitors or differentiated ones, with the properties of stemness. It is a question whether all tumor cells have the capacity for self renewal and unlimited growth or only a fraction of them, i.e. the tumor stem cells. The concept is challenging, since the existence of tumor stem cells has an important practical consequence: only stem cells should be removed or stopped in order to control the tumor, while the other cells have temporary proliferative capacity.
越来越多的证据支持肿瘤起源于体细胞干细胞或具有干性特征的细胞,这些细胞可以是祖细胞或分化细胞。所有肿瘤细胞是否都具有自我更新和无限生长的能力,还是只有一部分细胞,即肿瘤干细胞具有这种能力,这是一个问题。这一概念具有挑战性,因为肿瘤干细胞的存在具有重要的实际意义:为了控制肿瘤,只需清除或阻止干细胞,而其他细胞仅具有暂时的增殖能力。