• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Overcoming resistance: targeting the PI3K/mTOR pathway in endocrine refractory breast cancer.

作者信息

Butt Alison J

机构信息

Cancer Research Program, Garvan Institute of Medical Research and St. Vincent’s Clinical School, University of New South Wales, Sydney, Australia.

出版信息

Cancer Biol Ther. 2011 Jun 1;11(11):947-9. doi: 10.4161/cbt.11.11.15953.

DOI:10.4161/cbt.11.11.15953
PMID:21577052
Abstract
摘要

相似文献

1
Overcoming resistance: targeting the PI3K/mTOR pathway in endocrine refractory breast cancer.克服耐药性:靶向内分泌难治性乳腺癌中的PI3K/mTOR通路
Cancer Biol Ther. 2011 Jun 1;11(11):947-9. doi: 10.4161/cbt.11.11.15953.
2
Overcoming endocrine resistance in breast cancer: role of the PI3K and the mTOR pathways.克服乳腺癌内分泌耐药:PI3K 和 mTOR 通路的作用。
Expert Rev Anticancer Ther. 2013 Feb;13(2):143-7. doi: 10.1586/era.12.173.
3
Mechanisms of resistance in estrogen receptor positive breast cancer: overcoming resistance to tamoxifen/aromatase inhibitors.雌激素受体阳性乳腺癌的耐药机制:克服他莫昔芬/芳香化酶抑制剂的耐药性。
Curr Opin Pharmacol. 2018 Aug;41:59-65. doi: 10.1016/j.coph.2018.04.009. Epub 2018 Apr 30.
4
Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.通过共同靶向雷帕霉素哺乳动物靶蛋白、蛋白激酶B或丝裂原活化蛋白激酶激酶克服雌激素受体阳性乳腺癌中因PTEN水平降低导致的内分泌抵抗。
Breast Cancer Res. 2014 Sep 11;16(5):430. doi: 10.1186/s13058-014-0430-x.
5
G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer.G0S2 抑制 PI3K/mTOR 信号通路并增加乳腺癌对 PI3K/mTOR 通路抑制剂的敏感性。
Cell Cycle. 2017;16(21):2146-2155. doi: 10.1080/15384101.2017.1371884. Epub 2017 Sep 14.
6
[Antihormonal therapy in breast cancer and mTOR inhibitors].[乳腺癌的抗激素治疗与mTOR抑制剂]
Bull Cancer. 2011 Dec;98(12):1431-7. doi: 10.1684/bdc.2011.1496.
7
Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance.激素依赖性乳腺癌:靶向自噬和 PI3K 克服依西美坦获得性耐药。
J Steroid Biochem Mol Biol. 2018 Oct;183:51-61. doi: 10.1016/j.jsbmb.2018.05.006. Epub 2018 May 20.
8
Biological rationale for endocrine therapy in breast cancer.乳腺癌内分泌治疗的生物学原理。
Best Pract Res Clin Endocrinol Metab. 2004 Mar;18(1):1-32. doi: 10.1016/s1521-690x(03)00044-7.
9
[New therapeutical strategies in metastatic hormone-dependent breast cancer].[转移性激素依赖性乳腺癌的新治疗策略]
Bull Cancer. 2015 Apr;102(4):367-80. doi: 10.1016/j.bulcan.2015.02.013. Epub 2015 Mar 21.
10
Molecular characterization of anastrozole resistance in breast cancer: pivotal role of the Akt/mTOR pathway in the emergence of de novo or acquired resistance and importance of combining the allosteric Akt inhibitor MK-2206 with an aromatase inhibitor.乳腺癌阿那曲唑耐药的分子特征: Akt/mTOR 通路在新出现的或获得性耐药中的关键作用,以及联合应用变构 Akt 抑制剂 MK-2206 和芳香酶抑制剂的重要性。
Int J Cancer. 2013 Oct 1;133(7):1589-602. doi: 10.1002/ijc.28182. Epub 2013 May 2.

引用本文的文献

1
Endoplasmic reticulum stress promotes autophagy and apoptosis and reverses chemoresistance in human ovarian cancer cells.内质网应激促进人卵巢癌细胞的自噬和凋亡并逆转化疗耐药性。
Oncotarget. 2017 Jul 25;8(30):49380-49394. doi: 10.18632/oncotarget.17673.
2
Personalized therapy in endometrial cancer: challenges and opportunities.子宫内膜癌的个体化治疗:挑战与机遇。
Cancer Biol Ther. 2012 Jan 1;13(1):1-13. doi: 10.4161/cbt.13.1.18438.
3
Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells.
鉴定作为拓扑异构酶 I 催化抑制剂的环己酮衍生物:对他莫昔芬耐药 MCF-7 癌细胞的影响。
Invest New Drugs. 2012 Dec;30(6):2103-12. doi: 10.1007/s10637-011-9768-4. Epub 2011 Nov 22.