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使用两种门静脉高压模型研究麻醉剂对胃损伤的影响。

Effect of anesthetics on gastric damage using two models of portal hypertension.

作者信息

Câmara Paula Rs, Moi Gisele P, Ferraz José Geraldo P, Zeitune José Murilo R

机构信息

Paula RS Câmara, Gisele P Moi, UNIVAG, University Center of Várzea Grande, Mato Grosso, Brazil.

出版信息

World J Gastrointest Pharmacol Ther. 2010 Aug 6;1(4):81-6. doi: 10.4292/wjgpt.v1.i4.81.

DOI:10.4292/wjgpt.v1.i4.81
PMID:21577313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3091276/
Abstract

AIM: To investigate the effect of sodium pentobarbitone (SP) or ketamine/xylazine (KX) anesthetics on acute gastric injury. METHODS: Portal hypertension was induced by bile duct ligation (BDL) or portal vein stenosis (PVS). Ethanol (EtOH)-induced gastric damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow (GBF) was also measured by laser doppler flowmetry. RESULTS: EtOH-induced gastric damage was reduced in BDL rats under KX anesthesia in comparison to those under SP anesthesia. GBF dysfunction in fasted BDL rats was partially restored under KX anesthesia. In contrast, in fasted PVS rats, EtOH-induced gastric damage was increased under KX anesthesia while GBF was reduced. CONCLUSION: The use of KX anesthesia in experimental procedures involving cirrhotic rats (but not those with pure portal hypertension) is preferable to SP anesthesia.

摘要

目的：研究戊巴比妥钠（SP）或氯胺酮/赛拉嗪（KX）麻醉对急性胃损伤的影响。 方法：通过胆管结扎（BDL）或门静脉狭窄（PVS）诱导门静脉高压。采用离体胃腔实验评估乙醇（EtOH）诱导的胃损伤。同时用激光多普勒血流仪测量胃血流量（GBF）。 结果：与SP麻醉的BDL大鼠相比，KX麻醉的BDL大鼠中EtOH诱导的胃损伤减轻。禁食的BDL大鼠在KX麻醉下GBF功能障碍得到部分恢复。相反，在禁食的PVS大鼠中，KX麻醉下EtOH诱导的胃损伤增加而GBF减少。 结论：在涉及肝硬化大鼠（但不包括单纯门静脉高压大鼠）的实验过程中，使用KX麻醉优于SP麻醉。

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引用本文的文献

[1]
Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats.

World J Gastrointest Pathophysiol. 2012-8-15

本文引用的文献

[1]
Ablation of primary afferent neurons by neonatal capsaicin treatment reduces the susceptibility of the portal hypertensive gastric mucosa to ethanol-induced injury in cirrhotic rats.

Eur J Pharmacol. 2008-7-28

[2]
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J Am Assoc Lab Anim Sci. 2007-3

[3]
Differential effects of chloral hydrate- and ketamine/xylazine-induced anesthesia by the s.c. route.

Life Sci. 2006-9-20

[4]
Acute hyperglycemia induced by ketamine/xylazine anesthesia in rats: mechanisms and implications for preclinical models.

Exp Biol Med (Maywood). 2005-11

[5]
Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo.

Anesthesiology. 2004-12

[6]
Cardiorespiratory effects of diazepam-ketamine, xylazine-ketamine and thiopentone anesthesia in male Wistar rats--a comparative analysis.

Life Sci. 2004-8-27

[7]
Influence of different anaesthetics on pro-inflammatory cytokine expression in rat spleen.

Lab Anim. 2004-7

[8]
Effects of anesthetics on systemic hemodynamics in mice.

Am J Physiol Heart Circ Physiol. 2004-10

[9]
Glucose acts in the CNS to regulate gastric motility during hypoglycemia.

Am J Physiol Regul Integr Comp Physiol. 2003-11

[10]
Effects of ketamine/xylazine on expression of tumor necrosis factor-alpha, inducible nitric oxide synthase, and cyclo-oxygenase-2 in rat gastric mucosa during endotoxemia.

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