Vrethem Magnus, Lindahl Tomas
Department of Neurology and Neurophysiology;
Neurol Int. 2009 Nov 16;1(1):e11. doi: 10.4081/ni.2009.e11.
D-dimer levels in plasma, a degradation product of fibrin, have been shown to correlate with the severity of ischemic stroke. In order to investigate the outcome of patients with elevated D-dimer we have carried out a follow-up study of patients of 65 years of age and younger with acute ischemic stroke or transient ischemic attacks (TIA) admitted to our stroke unit from 1991 to 1992. Twenty-two of the 57 patients had elevated D-dimer levels in the plasma. High levels were associated with cardioembolic stroke. On follow-up after a mean of 12 years, 15 patients had died and six patients had suffered another stroke or TIA (three of whom were dead). Ten patients had suffered other cardiovascular events and seven of them were dead. We concluded that high levels of D-dimer in acute ischemic stroke patients on admission were associated with cardioembolic stroke and might have prognostic value for the development of further cardioor cerebrovascular events. Advanced age was found to be an independent risk factor.
血浆中的D - 二聚体水平是纤维蛋白的降解产物，已被证明与缺血性中风的严重程度相关。为了研究D - 二聚体升高患者的预后情况，我们对1991年至1992年入住我们卒中单元的65岁及以下急性缺血性中风或短暂性脑缺血发作（TIA）患者进行了一项随访研究。57名患者中有22名血浆D - 二聚体水平升高。高水平与心源性栓塞性中风相关。平均随访12年后，15名患者死亡，6名患者再次发生中风或TIA（其中3人死亡）。10名患者发生了其他心血管事件，其中7人死亡。我们得出结论，急性缺血性中风患者入院时D - 二聚体水平高与心源性栓塞性中风相关，可能对进一步发生心脑血管事件具有预后价值。高龄被发现是一个独立的危险因素。
