• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

4-(4-乙氧基苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二甲酯

Dimethyl 4-(4-ethoxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.

作者信息

Fun Hoong-Kun, Quah Ching Kheng, Reddy B Palakshi, Sarveswari S, Vijayakumar V

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 26;65(Pt 9):o2255-6. doi: 10.1107/S1600536809033364.

DOI:10.1107/S1600536809033364
PMID:21577652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2969859/
Abstract

In the title mol-ecule, C(19)H(23)NO(5), the dihedral angle formed by the benzene ring and the planar part of the dihydro-pyridine ring is 83.52 (5)°. The dihydro-pyridine ring adopts a flattened boat conformation. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, generating chains running parallel to [100]. The crystal structure is consolidated by C-H⋯O contacts.

摘要

在标题分子C(19)H(23)NO(5)中，苯环与二氢吡啶环平面部分形成的二面角为83.52 (5)°。二氢吡啶环呈扁平船式构象。在晶体中，分子通过N-H⋯O氢键相连，形成平行于[100]的链。晶体结构通过C-H⋯O接触得以巩固。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434c/2969859/508bf601f707/e-65-o2255-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434c/2969859/211deb6df8af/e-65-o2255-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434c/2969859/508bf601f707/e-65-o2255-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434c/2969859/211deb6df8af/e-65-o2255-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434c/2969859/508bf601f707/e-65-o2255-fig2.jpg

相似文献

1
Dimethyl 4-(4-ethoxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-(4-乙氧基苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二甲酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 26;65(Pt 9):o2255-6. doi: 10.1107/S1600536809033364.
2
Dimethyl 4-[3-(4-meth-oxy-phen-yl)-1-phenyl-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate dihydrate.4-[3-(4-甲氧基苯基)-1-苯基-1H-吡唑-4-基]-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二甲酯二水合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Jul 1;68(Pt 7):o2210-1. doi: 10.1107/S1600536812027936. Epub 2012 Jun 27.
3
Diethyl 4-(4-ethoxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-（4-乙氧基苯基）-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 26;65(Pt 9):o2247-8. doi: 10.1107/S160053680903339X.
4
Diethyl 4-(2,4-dichloro-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-(2,4-二氯苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 16;66(Pt 2):o363. doi: 10.1107/S1600536810001066.
5
Dimethyl 4-(3,4-dimethoxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-(3,4-二甲氧基苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二甲酸二甲酯
Acta Crystallogr Sect E Struct Rep Online. 2010 May 15;66(Pt 6):o1355-6. doi: 10.1107/S160053681001679X.
6
Diisobutyl 4-(3-eth-oxy-4-hy-droxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-(3-乙氧基-4-羟基苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二异丁酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o287-8. doi: 10.1107/S1600536811055334. Epub 2012 Jan 7.
7
Diethyl 4-[4-(dimethyl-amino)phen-yl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-[4-(二甲基氨基)苯基]-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 6;66(Pt 3):o519. doi: 10.1107/S1600536810003508.
8
Diethyl 2,6-dimethyl-4-(5-phenyl-1H-pyrazol-4-yl)-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.2,6 - 二甲基 - 4 -（5 - 苯基 - 1H - 吡唑 - 4 - 基）- 1,4 - 二氢吡啶 - 3,5 - 二羧酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o892-3. doi: 10.1107/S1600536812008173. Epub 2012 Feb 29.
9
Dimethyl 1,4-dihydro-4-(4-methoxy-phen-yl)-2,6-dimethyl-pyridine-3,5-dicarboxyl-ate.1,4 - 二氢 - 4 -（4 - 甲氧基 - 苯基）- 2,6 - 二甲基吡啶 - 3,5 - 二羧酸二甲酯
Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 13;66(Pt 3):o587-8. doi: 10.1107/S1600536810004940.
10
Diethyl 4-[5-(4-chloro-phen-yl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-[5-(4-氯苯基)-1H-吡唑-4-基]-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1289-90. doi: 10.1107/S160053681201344X. Epub 2012 Apr 4.

引用本文的文献

1
Dimethyl 1,4-dihydro-4-(4-methoxy-phen-yl)-2,6-dimethyl-pyridine-3,5-dicarboxyl-ate.1,4 - 二氢 - 4 -（4 - 甲氧基 - 苯基）- 2,6 - 二甲基吡啶 - 3,5 - 二羧酸二甲酯
Acta Crystallogr Sect E Struct Rep Online. 2010 Feb 13;66(Pt 3):o587-8. doi: 10.1107/S1600536810004940.

本文引用的文献

1
Diethyl 4-(4-ethoxy-phen-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxyl-ate.4-（4-乙氧基苯基）-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯
Acta Crystallogr Sect E Struct Rep Online. 2009 Aug 26;65(Pt 9):o2247-8. doi: 10.1107/S160053680903339X.
2
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
3
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
4
Quantitative structure-activity relationships for 1,4-dihydropyridine calcium channel antagonists (nifedipine analogues): a quantum chemical/classical approach.1,4-二氢吡啶类钙通道拮抗剂（硝苯地平类似物）的定量构效关系：一种量子化学/经典方法
J Pharm Sci. 1994 Aug;83(8):1110-5. doi: 10.1002/jps.2600830809.
5
Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers.1,4-二氢-2,6-二甲基-3-硝基-4-吡啶基吡啶-5-羧酸异丙酯外消旋体和对映体的合成、钙通道激动剂-拮抗剂调节活性及电压钳研究
J Med Chem. 1995 Jul 21;38(15):2851-9. doi: 10.1021/jm00015a007.
6
Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450.人肝微粒体对4-芳基和4-烷基取代的2,6-二甲基-3,5-双（烷氧羰基）-1,4-二氢吡啶的氧化作用以及细胞色素P-450某一形式参与其中的免疫化学证据。
J Med Chem. 1986 Sep;29(9):1596-603. doi: 10.1021/jm00159a007.
7
1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.1,4 - 二氢吡啶类化合物作为血小板活化因子拮抗剂。1. 2-(4-杂环基)苯基衍生物的合成及构效关系
J Med Chem. 1992 Aug 21;35(17):3115-29. doi: 10.1021/jm00095a005.
8
Synthesis of 3-[(2,3-dihydro-1,1,3-trioxo-1,2-benzisothiazol-2-yl)alkyl] 1,4-dihydropyridine-3,5-dicarboxylate derivatives as calcium channel modulators.作为钙通道调节剂的3-[(2,3-二氢-1,1,3-三氧代-1,2-苯并异噻唑-2-基)烷基]1,4-二氢吡啶-3,5-二羧酸酯衍生物的合成
J Med Chem. 1992 Jun 26;35(13):2407-14. doi: 10.1021/jm00091a008.