长臂猿致癌病毒的基因组稳定性

Genomic stability of gibbon oncornavirus.

作者信息

Sun L, Kawakami T G, Matoba S I

出版信息

J Virol. 1978 Dec;28(3):767-71. doi: 10.1128/JVI.28.3.767-771.1978.

DOI:10.1128/JVI.28.3.767-771.1978

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC525800/

Abstract

The 70S RNAs from several gibbon type C viruses were examined for sequence homology by molecular hybridization using complementary DNA probes. The sequence homology was found to vary with each virus isolate. The genome from one isolate was examined for genomic stability after the virus was experimentally passaged through three unrelated gibbons. The genomic homology remained unchanged after three passages, having greater than 93% homology based on complementary DNA-70S RNA hybridization and melting temperature analysis of the duplex. The genome from another isolate was similarly found to be unchanged after the virus was naturally transmitted in gibbons. The genomic variation found in the various isolates is not the consequence of recent horizontal transmission from a common virus.

摘要

使用互补DNA探针通过分子杂交检测了几种长臂猿C型病毒的70S RNA的序列同源性。发现序列同源性因每种病毒分离株而异。在病毒通过三只无关的长臂猿进行实验传代后，检测了一个分离株的基因组稳定性。传代三次后，基因组同源性保持不变，基于互补DNA-70S RNA杂交和双链体的解链温度分析，同源性大于93%。同样发现，在病毒在长臂猿中自然传播后，另一个分离株的基因组没有变化。在各种分离株中发现的基因组变异不是最近从共同病毒水平传播的结果。

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引用本文的文献

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J Virol. 1979 Sep;31(3):657-67. doi: 10.1128/JVI.31.3.657-667.1979.

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