• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

N'-[(E)-苄基亚甲基]-1-乙基-7-甲基-4-氧代-1,4-二氢-1,8-萘啶-3-碳酰肼

N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

作者信息

Deeba Farah, Khan Misbahul Ain, Zia-Ur-Rehman Muhammad, Sahin Ertan, Caylak Nagihan

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 21;65(Pt 12):o3152-3. doi: 10.1107/S1600536809048739.

DOI:10.1107/S1600536809048739
PMID:21578871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2972033/
Abstract

In the title compound, C(19)H(18)N(4)O(2), the 1,8-naphthyridine ring system is essentially planar [r.m.s. deviation = 0.011 (3) Å]. The dihedral angle between the naphthyridine ring system and the phenyl ring is 28.95 (7)°. The carbohydrazide H atom is involved in an intra-molecular N-H⋯O hydrogen bond, forming a six-membered hydrogen-bonded ring. In the crystal, the mol-ecules arrange themselves into centrosymmetric dimers by means of inter-molecular C-H⋯O hydrogen bonds.

摘要

在标题化合物C(19)H(18)N(4)O(2)中，1,8-萘啶环系基本呈平面状[r.m.s.偏差 = 0.011 (3) Å]。萘啶环系与苯环之间的二面角为28.95 (7)°。酰肼H原子参与分子内N-H⋯O氢键，形成一个六元氢键环。在晶体中，分子通过分子间C-H⋯O氢键排列成中心对称的二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26c/2972033/a80bf21b0f48/e-65-o3152-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26c/2972033/e779e7b94dc1/e-65-o3152-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26c/2972033/a80bf21b0f48/e-65-o3152-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26c/2972033/e779e7b94dc1/e-65-o3152-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c26c/2972033/a80bf21b0f48/e-65-o3152-fig2.jpg

相似文献

1
N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.N'-[(E)-苄基亚甲基]-1-乙基-7-甲基-4-氧代-1,4-二氢-1,8-萘啶-3-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 21;65(Pt 12):o3152-3. doi: 10.1107/S1600536809048739.
2
1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.1-乙基-N'-[(E)-4-羟基-亚苄基]-7-甲基-4-氧代-1,4-二氢-1,8-萘啶-3-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65(Pt 4):o860-1. doi: 10.1107/S1600536809009167.
3
(E)-N'-Benzyl-idene-5-methyl-isoxazole-4-carbohydrazide.（E）-N'-苄叉基-5-甲基异恶唑-4-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Dec 12;66(Pt 1):o123. doi: 10.1107/S1600536809052969.
4
(E)-5-Phenyl-N'-(1-phenyl-ethyl-idene)-1H-pyrazole-3-carbohydrazide.（E）-5-苯基-N'-（1-苯基-亚乙基）-1H-吡唑-3-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 21;64(Pt 1):o320. doi: 10.1107/S160053680706223X.
5
5-Methyl-N'-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-yl-idene]-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide.5-甲基-N'-[(3Z)-2-氧代-2,3-二氢-1H-吲哚-3-亚基]-1-苯基-1H-1,2,3-三唑-4-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2013 Mar 23;69(Pt 4):o577. doi: 10.1107/S1600536813007502. Print 2013 Apr 1.
6
N'-[(E)-4-Hydr-oxy-3-methoxy-benzyl-idene]pyridine-4-carbohydrazide.N'-[(E)-4-羟基-3-甲氧基-亚苄基]吡啶-4-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Oct 28;65(Pt 11):o2899. doi: 10.1107/S1600536809044134.
7
N'-[(5-Methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(thio-phen-2-yl)methyl-idene]benzohydrazide.N'-[(5-甲基-3-氧代-2-苯基-2,3-二氢-1H-吡唑-4-基)(噻吩-2-基)亚甲基]苯甲酰肼
Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1368-9. doi: 10.1107/S1600536812014821. Epub 2012 Apr 13.
8
(E)-N'-(2,3,4-Trihy-droxy-benzyl-idene)-isonicotinohydrazide dihydrate.（E）-N'-（2,3,4-三羟基苄叉基）异烟酰肼二水合物
Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 31;66(Pt 11):o3017-8. doi: 10.1107/S1600536810043965.
9
5-Fluoro-3-phenyl-N'-(4-propyl-cyclo-hexyl-idene)-1H-indole-2-carbohydrazide.5-氟-3-苯基-N'-(4-丙基-环己叉基)-1H-吲哚-2-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2013 Jul 6;69(Pt 8):o1202. doi: 10.1107/S1600536813018333. eCollection 2013.
10
Ethyl 2-[2-(4-hy-droxy-3-meth-oxy-benzyl-idene)hydrazin-1-yl-idene]-3,4-dimethyl-2,3-dihydro-1,3-thia-zole-5-carboxyl-ate.2-[2-(4-羟基-3-甲氧基苄叉基)肼-1-亚基]-3,4-二甲基-2,3-二氢-1,3-噻唑-5-羧酸乙酯
Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3213-4. doi: 10.1107/S1600536812043772. Epub 2012 Oct 27.

引用本文的文献

1
Methyl 1-ethyl-7-methyl-4-oxo-1,4-di-hydro-1,8-naphthyridine-3-carboxyl-ate monohydrate.1-乙基-7-甲基-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸甲酯一水合物
Acta Crystallogr Sect E Struct Rep Online. 2012 Mar 1;68(Pt 3):o630-1. doi: 10.1107/S1600536812004333. Epub 2012 Feb 10.

本文引用的文献

1
1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.1-乙基-N'-[(E)-4-羟基-亚苄基]-7-甲基-4-氧代-1,4-二氢-1,8-萘啶-3-碳酰肼
Acta Crystallogr Sect E Struct Rep Online. 2009 Mar 25;65(Pt 4):o860-1. doi: 10.1107/S1600536809009167.
2
Structure validation in chemical crystallography.化学晶体学中的结构验证
Acta Crystallogr D Biol Crystallogr. 2009 Feb;65(Pt 2):148-55. doi: 10.1107/S090744490804362X. Epub 2009 Jan 20.
3
A facile synthesis of novel biologically active 4-hydroxy-N'-(benzylidene)-2H-benzo[e][1,2]thiazine-3-carbohydrazide 1,1-dioxides.
新型生物活性4-羟基-N'-(亚苄基)-2H-苯并[e][1,2]噻嗪-3-碳酰肼1,1-二氧化物的简便合成方法。
Eur J Med Chem. 2009 Mar;44(3):1311-6. doi: 10.1016/j.ejmech.2008.08.002. Epub 2008 Aug 13.
4
A short history of SHELX.SHELX简史。
Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22. doi: 10.1107/S0108767307043930. Epub 2007 Dec 21.
5
Synthesis of potential biologically active 1,2-benzothiazin-3-yl-quinazolin-4(3H)-ones.潜在生物活性1,2-苯并噻嗪-3-基喹唑啉-4(3H)-酮的合成
Chem Pharm Bull (Tokyo). 2006 Aug;54(8):1175-8. doi: 10.1248/cpb.54.1175.
6
Recognition of guanine-guanine mismatches by the dimeric form of 2-amino-1,8-naphthyridine.2-氨基-1,8-萘啶二聚体对鸟嘌呤-鸟嘌呤错配的识别。
J Am Chem Soc. 2001 Dec 19;123(50):12650-7. doi: 10.1021/ja0109186.
7
Synthesis and antibacterial evaluation of certain quinolone derivatives.某些喹诺酮衍生物的合成与抗菌活性评价
J Med Chem. 2001 Jul 5;44(14):2374-7. doi: 10.1021/jm0100335.
8
Gold(I) and silver(I) metallocryptates based on 2,9-bis(diphenylphosphino)-1,8-naphthyridine.基于2,9-双（二苯基膦基）-1,8-萘啶的金（I）和银（I）金属穴合物
Inorg Chem. 2000 Jan 10;39(1):121-7. doi: 10.1021/ic9908827.
9
1,8-Naphthyridines IV. 9-substituted N,N-dialkyl-5-(alkylamino or cycloalkylamino) [1,2,4]triazolo[4,3-a][1, 8]naphthyridine-6-carboxamides, new compounds with anti-aggressive and potent anti-inflammatory activities.1,8-萘啶IV. 9-取代的N,N-二烷基-5-(烷基氨基或环烷基氨基)[1,2,4]三唑并[4,3-a][1,8]萘啶-6-甲酰胺，具有抗攻击和强效抗炎活性的新化合物。
Eur J Med Chem. 2000 Nov;35(11):1021-35. doi: 10.1016/s0223-5234(00)01175-2.
10
Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2, 3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2, 3-b]pyridine:potential antihypertensive agents - part IX.2,3-二氢-1,8-萘啶和2,3-二氢硫代吡喃并[2,3-b]吡啶的（R,S）-（E）-肟醚的合成及β-阻断活性：潜在的抗高血压药物 - 第九部分。
Eur J Med Chem. 2000 Sep;35(9):815-26. doi: 10.1016/s0223-5234(00)00173-2.