Egli M, Gessner R V, Williams L D, Quigley G J, van der Marel G A, van Boom J H, Rich A, Frederick C A
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Proc Natl Acad Sci U S A. 1990 Apr;87(8):3235-9. doi: 10.1073/pnas.87.8.3235.
Cyclic diguanylic acid acts as a regulator for cellulose synthase activity in the bacterium Acetobacter xylinum. We report the x-ray crystal structure of the regulator at atomic resolution. The structure contains two independent molecules that adopt almost identical conformations. The two molecules form self-intercalated units that are stacked on each other. Two different G.G base-pairing modes occur between the stacks. The more stable one has two or possibly three hydrogen bonds between two guanines and is related to the type of hydrogen bonding that is believed to exist between G-rich strands at the ends of chromosomes.
环二鸟苷酸作为木醋杆菌中纤维素合酶活性的调节剂。我们报告了该调节剂在原子分辨率下的X射线晶体结构。该结构包含两个采用几乎相同构象的独立分子。这两个分子形成相互插层的单元，相互堆叠。在堆叠之间出现两种不同的G.G碱基配对模式。更稳定的一种在两个鸟嘌呤之间有两个或可能三个氢键，并且与据信存在于染色体末端富含G的链之间的氢键类型有关。
