大鼠体内尿中环磷酸腺苷（cAMP）对降钙素和甲状旁腺激素反应的来源
Source of urinary cyclic AMP in response to calcitonin and parathyroid hormone in the rat.
作者信息
Firek A F, Ramanathan S, Suh S M
机构信息
Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.
出版信息
Res Commun Chem Pathol Pharmacol. 1990 Jan;67(1):147-50.
Administration of calcitonin (CT) or parathyroid hormone (PTH) in rats, induced phosphaturia with a concomitant increase in urinary excretion of cyclic AMP. CT produced a rise in arterial cAMP and filtered cAMP, with no increase in urinary nephrogenous cAMP. PTH on the other hand, produced an elevation in urinary nephrogenous cAMP with no increase in arterial cAMP and filtered cAMP. These results indicate that the source of urinary cAMP after CT is non-renal, whereas after PTH it is renal in origin.
给大鼠注射降钙素（CT）或甲状旁腺激素（PTH）可诱发磷尿症，并伴有环磷酸腺苷（cAMP）尿排泄增加。CT使动脉血cAMP和滤过cAMP升高，而尿源性cAMP无增加。另一方面，PTH使尿源性cAMP升高，而动脉血cAMP和滤过cAMP无增加。这些结果表明，CT后尿cAMP的来源是非肾脏的，而PTH后其来源是肾脏的。
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