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执行功能障碍综合征行为评估的可靠性研究,该评估适用于巴西老年对照组和可能的早期阿尔茨海默病患者样本。

Reliability study of the Behavioral Assessment of the Dysexecutive Syndrome adapted for a Brazilian sample of older-adult controls and probable early Alzheimer's disease patients.

机构信息

Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

出版信息

Braz J Psychiatry. 2011 Dec;33(4):338-46. doi: 10.1590/s1516-44462011005000015. Epub 2011 May 13.

Abstract

OBJECTIVE

Ecological tests are useful in assessing executive function deficits and may be of value in appraising response to treatment in Alzheimer's disease patients. Our aims were to examine executive function using the Behavioral Assessment of the Dysexecutive Syndrome for a Brazilian sample of older-adult controls and probable early Alzheimer's disease patients, and verify the applicability of this test battery.

METHOD

Forty-one older-adult controls were matched with mild Alzheimer's disease patients by age, education, and gender.

RESULTS

There significant inter-group differences in overall profile and almost all subtests except temporal judgment, time spent on planning the first and second Zoo Map visit, number of errors when copying drawings, naming pictures and Six Modified Elements arithmetic, and dysexecutive questionnaire self-rating. The Behavioral Assessment of the Dysexecutive Syndrome item that best discriminated controls from patients was the Modified Six Elements - adapted (general index), with a sensitivity of 80% and specificity of 90%, (AUC = 0.91, p < 0.001).

CONCLUSION

Behavioral Assessment of the Dysexecutive Syndrome was effective in detecting executive function deficits in mild Alzheimer's disease patients, particularly the task switching, time monitoring, and rule-shift subtests.

摘要

目的

生态测试在评估执行功能缺陷方面很有用,并且可能有助于评估阿尔茨海默病患者的治疗反应。我们的目的是使用行为评估的执行功能障碍综合征对巴西老年对照组和可能的早期阿尔茨海默病患者进行检查,并验证该测试组合的适用性。

方法

将 41 名老年对照组与轻度阿尔茨海默病患者按年龄、教育程度和性别相匹配。

结果

在整体特征和几乎所有子测试中,除了时间判断、第一次和第二次动物园地图访问的规划时间、临摹图画时的错误数、命名图片和六个改良元素算术以及执行功能障碍问卷自评外,两组间均存在显著差异。区分对照组和患者的行为评估的执行功能障碍综合征项目是改良的六个元素-适应(总指数),具有 80%的敏感性和 90%的特异性(AUC=0.91,p<0.001)。

结论

行为评估的执行功能障碍综合征在检测轻度阿尔茨海默病患者的执行功能缺陷方面非常有效,特别是任务转换、时间监测和规则转换子测试。

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