Laway Bashir Ahmad, Mir Shahnaz Ahmad, Dar Mohd Iqbal, Zargar Abdul Hamid
Department of Endocrinology, Srinagar, Jammu and Kashmir, India.
Arq Bras Endocrinol Metabol. 2011 Mar;55(2):171-4. doi: 10.1590/S0004-27302011000200010.
Sheehan's syndrome refers to the occurrence of hypopituitarism after delivery, usually preceded by postpartum hemorrhage. The condition still continues to be a common cause of hypopituitarism in developing countries like India. The disorder usually presents with anterior pituitary failure with preservation of posterior pituitary functions. Posterior pituitary dysfunction in the form of central diabetes insipidus is rare in patients with Sheehan's syndrome. We describe the clinical course of a young lady who after her sixth childbirth developed severe postpartum hemorrhage followed by development of panhypopituitarism which was confirmed by hormonal investigation and demonstration of empty sella on imaging. In addition, she developed Polyuria. The water deprivation test and response to vasopressin test results indicated central diabetes insipidus. She needed oral desmopressin on a continuous basis to control polyuria.
席汉综合征是指产后发生垂体功能减退，通常在产后出血之后出现。在印度等发展中国家，这种病症仍是垂体功能减退的常见病因。该疾病通常表现为垂体前叶功能衰竭，而后叶功能得以保留。在席汉综合征患者中，以中枢性尿崩症形式出现的垂体后叶功能障碍较为罕见。我们描述了一位年轻女性的临床病程，她在第六次分娩后发生严重产后出血，随后发展为全垂体功能减退，这通过激素检查及影像学显示的空蝶鞍得以证实。此外，她出现了多尿症状。禁水-加压素试验结果表明为中枢性尿崩症。她需要持续口服去氨加压素以控制多尿。
