Diri Halit, Karaca Zuleyha, Tanriverdi Fatih, Unluhizarci Kursad, Kelestimur Fahrettin
Department of Endocrinology, Erciyes University Medical School, 38039, Kayseri, Turkey.
Endocrine. 2016 Jan;51(1):22-31. doi: 10.1007/s12020-015-0726-3. Epub 2015 Sep 1.
Sheehan's syndrome (SS) is a parturition-related pituitary disease resulting from severe postpartum hemorrhage and can present with varying degrees of pituitary insufficiency. Pathological and clinical findings of SS were first described by Harold L. Sheehan in the previous century. Although his definitions are still valid, various studies and reports including new data have subsequently been published. Additionally, the diagnosis of SS has often been overlooked and thus delayed for long years due to its nonspecific signs and symptoms. Therefore, a large number of patients may be remained undiagnosed and untreated. SS is not as rare as assumed in developed countries, probably due to migrant women and unawareness of physicians regarding the syndrome. In this review, we provide a detailed review of the epidemiology, etiopathogenesis, clinical, laboratory and radiological features, new diagnostic criteria, differential diagnosis, and treatment of SS.
席汉综合征（SS）是一种与分娩相关的垂体疾病，由严重产后出血引起，可表现为不同程度的垂体功能减退。SS的病理和临床发现最早由哈罗德·L·席汉在上个世纪描述。尽管他的定义仍然有效，但随后包括新数据在内的各种研究和报告相继发表。此外，由于其非特异性体征和症状，SS的诊断常常被忽视，从而延误多年。因此，大量患者可能未被诊断和治疗。在发达国家，SS并不像人们认为的那么罕见，这可能归因于移民妇女以及医生对该综合征认识不足。在本综述中，我们对SS的流行病学、病因发病机制、临床、实验室和放射学特征、新的诊断标准、鉴别诊断及治疗进行了详细阐述。
