Van Beers Bernard E, Doblas Sabrina, Sinkus Ralph
Department of Radiology and IPMA, INSERM UMR773, Beaujon University Hospital, University of Paris Diderot, 100 Avenue du General Leclerc, 92110, Clichy, France.
Abdom Imaging. 2012 Apr;37(2):155-63. doi: 10.1007/s00261-011-9748-3.
Conventional MR imaging of the liver has a central role in the assessment of liver diseases. Diffusion-weighted MR imaging, MR elastography, and time-resolved dynamic contrast-enhanced MR imaging improve the anatomical information provided by conventional MR imaging and add quantitative functional information in diffuse and focal liver diseases. Particularly, accurate detection and characterization of liver fibrosis are feasible with quantitative MR elastography, detection of liver tumors is increased with diffusion-weighted MR imaging and time-resolved dynamic contrast-enhanced MR imaging, characterization of tumors can be improved with quantitative diffusion-weighted MR imaging and MR elastography. These methods also have the potential to provide adequate biomarkers for assessing the response to treatment. Currently, the main limitations of quantitative MR imaging are related to reproducibility, standardization, and/or limited clinical data. It is important to improve and standardize the quantitative MR methods and validate their role in large multicenter trials.
肝脏的传统磁共振成像在肝脏疾病评估中发挥着核心作用。扩散加权磁共振成像、磁共振弹性成像和时间分辨动态对比增强磁共振成像改善了传统磁共振成像提供的解剖信息，并在弥漫性和局灶性肝脏疾病中增加了定量功能信息。特别是，通过定量磁共振弹性成像可以准确检测和表征肝纤维化，通过扩散加权磁共振成像和时间分辨动态对比增强磁共振成像可提高肝肿瘤的检测率，通过定量扩散加权磁共振成像和磁共振弹性成像可改善肿瘤的表征。这些方法还有潜力提供足够的生物标志物来评估治疗反应。目前，定量磁共振成像的主要局限性与可重复性、标准化和/或有限的临床数据有关。改进和标准化定量磁共振方法并在大型多中心试验中验证其作用非常重要。
